The Impact of a One-Dose versus Two-Dose Oral Cholera Vaccine Regimen in Outbreak Settings: A Modeling Study |
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| Authors: | Andrew S Azman Francisco J Luquero Iza Ciglenecki Rebecca F Grais David A Sack Justin Lessler |
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| Institution: | 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;2Epicentre, Paris, France;3Médecins Sans Frontières, Geneva, Switzerland;4Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;The National Institute for Public Health and the Environment, NETHERLANDS |
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| Abstract: | BackgroundIn 2013, a stockpile of oral cholera vaccine (OCV) was created for use in outbreak response, but vaccine availability remains severely limited. Innovative strategies are needed to maximize the health impact and minimize the logistical barriers to using available vaccine. Here we ask under what conditions the use of one dose rather than the internationally licensed two-dose protocol may do both.ConclusionsReactive vaccination campaigns using a single dose of OCV may avert more cases and deaths than a standard two-dose campaign when vaccine supplies are limited, while at the same time reducing logistical complexity. These findings should motivate consideration of the trade-offs between one- and two-dose campaigns in resource-constrained settings, though further field efficacy data are needed and should be a priority in any one-dose campaign. |
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