| 人参皂甙Rb1对大鼠脑缺血再灌注神经损伤后的修复作用 |
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| 引用本文： | 李明强,曾照芳,尤萍.人参皂甙Rb1对大鼠脑缺血再灌注神经损伤后的修复作用[J].生物信息学,2011,9(2):155-156,163. |
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| 作者姓名： | 李明强 曾照芳 尤萍 |
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| 作者单位： | 重庆医科大学检验系,临床检验诊断学教育部重点实验室,重庆400016,China |
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| 摘 要： | 通过阻塞大鼠大脑动脉,制备短暂性脑缺血大鼠模型,将出现神经功能缺失症状的大鼠随机分组,实施再灌注后立即按(40mg/kg)进行腹腔注射人参皂甙Rb1。结果发现大鼠脑缺血再灌注后,人参皂甙Rb1通过促进NAIP、Bcl-2表达和抑制Bax表达发挥神经损伤后的修复作用。人参皂甙Rb1给药组在各时间点的胶质细胞源性神经营养因子(GDNF)阳性细胞数远远高于单纯脑缺血再灌注组(P<0.01)。GDNF的表达与缺血性损伤有一定的联系,可认为人参皂甙Rbl对神经系统有一定保护作用。
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| 关 键 词： | 人参皂甙Rb1 大鼠 脑缺血再灌注 神经损伤 修复 |
Ginsenoside Rb1 on cerebral ischemia-reperfusion nerve injury repair |
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| LI Ming-qiang,ZENG Zhao-fang,YOU Ping.Ginsenoside Rb1 on cerebral ischemia-reperfusion nerve injury repair[J].China Journal of Bioinformation,2011,9(2):155-156,163. |
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| Authors: | LI Ming-qiang ZENG Zhao-fang YOU Ping |
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| Institution: | LI Ming-qiang ZENG Zhao-fang* YOU Ping *(Key Laboratory of Laboratory Medical Diagnostics,Ministry of Education,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Cerebral artery through the occlusion,preparation transient ischemic rat model,there will be symptoms of neurological deficits in rats were randomly assigned to implement immediately after reperfusion by(40mg/kg) intraperitoneal injection of ginsenoside Rb1.The results showed that after cerebral ischemia in rats,ginsenoside Rb1 by promoting the NAIP,Bcl-2 expression and inhibit the expression of Bax play a role in nerve repair after injury.Ginsenoside Rb1 treatment group at all time points of glial cell lin... |
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| Keywords: | Ginsenoside Rbl Rats Ischemia-reperfusion Nerve injury Repair |
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