| 链球菌属纤连蛋白结合蛋白的生物信息学分析 |
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| 引用本文： | 周益装,尤元海,张建中.链球菌属纤连蛋白结合蛋白的生物信息学分析[J].生物信息学,2011,9(1):60-64. |
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| 作者姓名： | 周益装 尤元海 张建中 |
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| 作者单位： | 中国疾病预防控制中心传染病预防控制所,北京,102206 |
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| 基金项目： | 受“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项:《传染病检测技术研究-传染病病原体诊断和组合检测技术》项目(编号:2008ZX10004-002)资助 |
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| 摘 要： | 对链球菌属纤连蛋白结合蛋白进行系统的分析,找出其特征,为以后的研究奠定基础。通过MUSCLE、BLASTP、PSI-BLAST、PHYLIP、Perl编程等生物信息学方法对217条候选纤连蛋白结合蛋白进行研究。发现共有31个序列纤连蛋白结合蛋白重复单元序列模体,绝大部分蛋白由两个或两个以上的不同模体序列构成,其保守结构域组合呈现多样性等特征。表明链球菌属纤连蛋白结合蛋白重复单元序列模体不是严格统一的,总体上具有变异性,但模体之间又有很大的相似性。
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| 关 键 词： | 生物信息学 纤连蛋白结合蛋白 链球菌属 |
Bioinformatics analysis for fibronectin-binding proteins of Streptococcus |
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| ZHOU Yi-zhuang,YOU Yuan-hai,ZHANG Jian-zhong.Bioinformatics analysis for fibronectin-binding proteins of Streptococcus[J].China Journal of Bioinformation,2011,9(1):60-64. |
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| Authors: | ZHOU Yi-zhuang YOU Yuan-hai ZHANG Jian-zhong |
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| Institution: | ZHOU Yi-zhuang,YOU Yuan-hai,ZHANG Jian-zhong (National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China) |
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| Abstract: | To systematically analyze fibronectin-binding proteins of streptococcs to discover features and build firm foundation for following researches,bioinformatics tools such as MUSCLE、BLASTP、PSI-BLAST、PHYLIP、Perl language programming et al were used to analyze 217 candicate fibronectin-binding proteins.Features include 31 fibronectin-binding protein repeat（FR） sequence motifs、conserved domain divergence、most fibronectin-binding proteins having at least two different motifs and so on.FR motifs of genus streptococcus are not stringently unified,but with similarity among motifs. |
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| Keywords: | bioinformatics fibronectin-binding protein genus streptococcus |
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