| 乙型肝炎病毒B2和C2亚型中SSRs的比较分析 |
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| 引用本文： | 冯海平,谭钟扬,李丹,赵相艳,李明福,欧阳清检.乙型肝炎病毒B2和C2亚型中SSRs的比较分析[J].生物信息学,2011,9(4):275-280. |
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| 作者姓名： | 冯海平 谭钟扬 李丹 赵相艳 李明福 欧阳清检 |
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| 作者单位： | 1. 湖南大学,湖南长沙,410082
2. 中国检验检疫科学研究所,北京,100029 |
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| 基金项目： | 湖南省科技计划项目，十一五支撑计划 |
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| 摘 要： | 乙型肝炎病毒(hepatitis B virus,HBV)属于嗜肝DNA病毒科(hepadnaviridae),它分布在世界各地并严重危害人类的健康。本文从NCBI的GenBank中下载了106条B2亚型和130条C2亚型的基因组全长序列,以下载的数据为材料,分析简单重复序列(simple sequence repeats,SSRs)在B2和C2亚型基因组序列中的分布情况。结果显示,简单重复序列的重复次数比较少;二型简单重复序列在研究的五种简单重复序列类型中占绝对优势;这可能与B2和C2亚型基因组序列有较高的突变率有关。同时还发现最普遍的SSRs、序列间SSRs的平均相对丰度和平均相对密度在B2和C2亚型中分布情况相似。
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| 关 键 词： | 简单重复序列 乙型肝炎病毒 亚型 |
Comparison of simple sequence repeats between subgenotypes B2 and C2 of hepatitis B virus |
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| FENG Hai-ping,TAN Zhong-yang,LI Dan,ZHAO Xiang-yan,LI Ming-fu,OUYANG Qing-jian.Comparison of simple sequence repeats between subgenotypes B2 and C2 of hepatitis B virus[J].China Journal of Bioinformation,2011,9(4):275-280. |
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| Authors: | FENG Hai-ping TAN Zhong-yang LI Dan ZHAO Xiang-yan LI Ming-fu OUYANG Qing-jian |
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| Institution: | FENG Hai-ping1,TAN Zhong-yang1,LI Dan1,ZHAO Xiang-yan1,LI Ming-fu2,OUYANG Qing-jian1 (1.Hunan University,Hunan Changsha 410082,China:2.Chinese Academy of Inspection and Quarantine,Beijing 100029,China) |
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| Abstract: | Hepatitis B virus (HBV) belonging to the family hepadnaviridae is notorious pathogen with world-wild distribution.106 and 130 complete genome sequences for subgenotypes B2 and C2 respectively were downloaded from Genbank of NCBI in this study,and scanning complete genome sequences,the distribution of simple sequence repeats (SSRs) was analyzed.It has been showed that the numbers of repeats were low and dinucleotide repeats were predominant in all analyzed SSRs types in this study.It might be related to the ... |
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| Keywords: | simple sequence repeat hepatitis B virus subgenotype |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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