Helicobacter pylori 26695 基因组尺度代谢研究进展

代谢网络在代谢功能研究、生物代谢过程控制、疾病诊断分析和药物靶标设计等方面具有重要理论和实践意义。生物信息学研究利用序列同源、结构模拟、对接等手段与生化实验有效结合促进了生物体代谢网络的进一步完善。本文作者在构建幽门螺杆菌（Helicobacter pylori 26695,H.pylori 26695）代谢网络的工作基础上综合了近年来研究者对H.pylori 26695代谢通路关键酶的研究成果,并结合基因组信息,综述了H.pylori 26695特异性的重要代谢通路。本文从基因组水平阐明代谢通路与基因的关系,并详细分析了关键酶对H.pylori 26695生理的重要作用,最后探讨了重构一个连续、完整的代谢网络面临的困难及其在药物靶标设计方面的研究前景。

Progress in genome-scale metabolism of Helicobacter pylori26695

Metabolic network is widely used in metabolic studies, biological metabolic process control, disease diagnosis and drug target design. Bioinformatics studies are now combined with biochemical experiments effectively by the means of sequence homologous, structure simulation and docking to promote the completion of organism metabolic network. Based on the knowledge of genome-scale metabolic network reconstruction for H. pylori, we reviewed several important metabolic pathways by combining the recent achievements on key enzyme researches of Helicobacter pylori 26695 （H.pylori） as well as genome information.We revealed the relationship between genes and metabolic pathway and analyzed the vital functions of key enzymes in H. pylori. Lastly, the challenges in reconstructing a coherent, complete metabolic network are introduced in this paper and the perspectives in drug target designing are also discussed.