| 线粒体CytC的释放机制及其在细胞凋亡中的作用 |
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| 引用本文： | 李宏,冯有胜.线粒体CytC的释放机制及其在细胞凋亡中的作用[J].生物信息学,2010,8(3):210-213. |
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| 作者姓名： | 李宏 冯有胜 |
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| 作者单位： | 重庆工商大学环境与生物工程学院,重庆,400067 |
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| 基金项目： | 重庆市科委应用基础研究项目 |
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| 摘 要： | 描述了细胞色素C(CytC)从线粒体释放的机制及其在细胞凋亡中的作用,主要阐述了细胞凋亡信号转导途径中的线粒体-CytC途径及AIF途径;CytC在细胞凋亡中的作用及介导细胞凋亡的方式。探讨了线粒体CytC的泄漏机制,对非特异性释放模式(MPTP假说和线粒体膨胀假说)、特异性释放模式(专一性通道假说)进行了阐述,最后分析了研究CytC与细胞凋亡分子机制的意义并提出细胞凋亡分子机制中一些未完全研究清楚的问题。
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| 关 键 词： | Apaf-2/CytC 细胞凋亡途径 线粒体 泄漏 |
Mechanism of mitchondria Cyt C release and its action on apoptosis |
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| LI Hong,FENG You-sheng.Mechanism of mitchondria Cyt C release and its action on apoptosis[J].China Journal of Bioinformation,2010,8(3):210-213. |
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| Authors: | LI Hong FENG You-sheng |
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| Institution: | (Chongqing Business and Technology University,Environmental and Biological Engineering,chongqing 400067,China) |
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| Abstract: | The mechanism of mitochondria CytC release and its action on apoptosis were described.It has mainly set forth the mitochondria-CytC pathway and AIF pathway of signal transferring in apoptosis,the action of CytC on apoptosis and the manner of CytC mediating the apoptosis.It has also discussed the mechanism of CytC leakage in the mitochondria,and set forth the nonspecific releasing mode（MPTP hypothesis and mitochondria swelling hypothesis） and the specific releasing mode（specific tunnel hypothesis）.Finally,it has analyzed the meaning of studying the molecular mechanism of CytC-mediated apoptosis,and put forward the problem existed in the research of the molecular mechanism of apoptosis. |
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| Keywords: | Apaf-2/CytC |
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