C反应蛋白检测在感染性和非感染性发热鉴别中的作用

目的：探讨C反应蛋白（C reactive protein,CRP）在感染性和非感染性发热鉴别中的作用。方法：对758例以发热为主要症状的患者进行各项检查,并在入院24小时内采集静脉血用免疫比浊法检测CRP,计算特异度、灵敏度、准确度、阳性预测值、阴性预测值、阳性似然比、阴性似然比。结果：758例患者中,确诊为感染性发热的患者616例,占81.27%,非感染性发热患者142例,占18.73%。感染性发热患者的CRP值显著高于非感染性发热患者,差异具有统计学意义（P〈0.05）。CRP检验的特异度、灵敏度、准确度、阳性预测值、阴性预测值、阳性似然比和阴性似然比的值分别为87.32%、97.89%、95.91%、97.10%、90.51%、7.72和0.02。结论：CRP的检测能有效鉴别感染性发热与非感染性发热。

Effectiveness of Differential Diagnosis of Infectious and Non-Infectious Fever by C-Reactive Protein Examination

Objective： To study the role of C-reactive protein（CRP） in differential diagnosis of infectious and non-infectious fever. Methods： 758 patients presenting fever were enrolled in this study. CRP was determined within the first 24h of hospitalization by immune turbidimetry, as well as other examinations. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio were calculated. Results： 616 patients were diagnosed as infectious fever （81.27%）; 142 patients as non-infectiousfever （18.73%）. The CRP in infectious fever patients were significant higher than that in non-infected patients, the difference was significant in statistics （P 〈0.05）. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio were87.32%, 97.89%, 95.91%, 97.10%, 90.51%, 7.72 and 0.02, respectively. Conclusion： CRP test can identify fever with infection or non-infectious effectively.