微创胸腔闭式引流精密可控负压吸引术治疗原发性自发性气胸的疗效及患者疼痛、氧化应激反应观察

摘要 目的：探究微创胸腔闭式引流精密可控负压吸引术治疗原发性自发性气胸（PSP）的疗效及对患者疼痛、氧化应激反应的影响。方法：选取2019年1月~2021年1月我院收治的PSP患者120例，以随机数表法分成研究组与对照组，各自60例。给予对照组微创胸腔常规闭式引流治疗，研究组则给予微创胸腔闭式引流精密可控负压吸引术治疗。比较两组患者的临床疗效，术后6 h、1 d及3 d的疼痛评分（VAS），术前及术后1 d的血清氧化应激指标超氧化物歧化酶（SOD）、丙二醛（MDA）]水平以及术后并发症发生情况。结果：研究组临床疗效的总有效率为91.67%，显著高于对照组的78.33%（P<0.05），且研究组患者术后6 h、术后1 d以及术后3 d的VAS评分均显著低于对照组（P<0.05）。术后研究组患者SOD水平显著高于对照组（P<0.05），同时MDA水平显著低于对照组（P<0.05）。另外研究组患者的总并发症发生率为3.33%，显著低于对照组的13.33%（P<0.05）。结论：微创胸腔闭式引流精密可控负压吸引术治疗PSP的疗效肯定，能减轻患者的疼痛程度及氧化应激反应，且能减少术后并发症的发生率。

Curative Effect of Minimally Invasive Closed Thoracic Drainage with Precise Controllable Negative Pressure Suction on Primary Spontaneous Pneumothorax and its Influences on Pain and Oxidative Stress

ABSTRACT Objective: To explore the curative effect of minimally invasive closed thoracic drainage with precise controllable negative pressure suction on primary spontaneous pneumothorax (PSP) and its influences on pain and oxidative stress. Methods: A total of 120 patients with PSP admitted to the hospital were enrolled between January 2019 and January 2021. According to random number table method, they were divided into study group and control group, 60 cases in each group. The control group was given routine minimally invasive closed thoracic drainage, while study group was given minimally invasive closed thoracic drainage with precise controllable negative pressure suction. The clinical curative effect, scores of visual analogue scale (VAS) at 6 h, 1 d and 3 d after surgery, serum oxidative stress indexes superoxide dismutase (SOD), malondialdehyde (MDA)] before and at 1d after surgery, and occurrence of postoperative complications were compared between the two groups. Results: The total response rate of clinical curative effect in study group was significantly higher than that in control group (91.67% vs 78.33%, P<0.05). At 6 h, 1 d and 3 d after surgery, VAS scores in study group were significantly lower than those in control group(P<0.05). After surgery, SOD level in study group was significantly higher than that in control group (P<0.05), while MDA level was significantly lower than that in control group (P<0.05). The total incidence of complications in study group was significantly lower than that in control group(3.33% vs 13.33%, P<0.05). Conclusion: Curative effect of minimally invasive closed thoracic drainage with precise controllable negative pressure suction is significant on PSP, which can relieve pain and oxidative stress response, and reduce the incidence of postoperative complications.