氨基酮戊酸光动力联合一清片治疗中重度痤疮效果及对血清学指标的影响

摘要 目的：观察氨基酮戊酸光动力联合一清片治疗中重度痤疮疗效以及对血清学指标的影响。方法：将93例中重度痤疮患者进行随机分组，31例为治疗组，31例为参照组1，31例为参照组2。治疗组采用氨基酮戊酸光动力联合一清片治疗，参照组1采用氨基酮戊酸光动力治疗，参照组2采用一清片治疗，观察三组治疗前、后患者痤疮严重程度分级系统(GAGS)评分、痤疮特异性生活质量量表（Qol-Acne）评分变化及性激素结合球蛋白（SHBG）、游离睾酮（FT）、雌二醇（E₂）、补体C3、免疫球蛋白IgG、IgM水平，比较三组临床疗效。结果：治疗组FT水平低于参照组1和参照组2（P＜0.05），治疗组SHBG、E₂水平高于参照组1和参照组2（P＜0.05），治疗组补体C3、IgG、IgM水平低于参照组1和参照组2（P＜0.05），治疗组Qol-Acne评分较参照组1和参照组2高（P＜0.05），治疗组GAGS评分较参照组1和参照组2低（P＜0.05），治疗组总有效率（93.55%）高于参照组1（77.42%）和参照组2（64.52%）（P＜0.05）。结论：氨基酮戊酸光动力联合一清片治疗中重度痤疮患者，可调节患者内分泌，改善性激素水平及免疫状态，缓解患者痤疮症状，提升生活质量及临床疗效。

Effect of Aminolevulinic Acid Photodynamic Combined with Yiqing Tablet in the Treatment of Moderate to Severe Acne and its Influence on Serological Indexes

ABSTRACT Objective: To observe the efficacy of aminolevulinic acid photodynamic combined with Yiqing Tablets in the treatment of moderate to severe acne and its influence on serological indexes. Methods: Ninety-three patients with moderate to severe acne were randomly assigned, 31 were in the treatment group, 31 were in the Reference group, 31 were in the Reference group1, and 31 were in the Reference group 2. Treatment group was treated with amino ketovaleric acid photodynamic therapy combined with Yiqing tablet, reference group 1 was treated with amino ketovaleric acid photodynamic therapy, and reference group 2 was treated with Yiqing tablet. The changes of global acne grading system(GAGS) score, acne-specific quality of life scale(Qol-Acne) score and sex hormone binding globulin(SHBG), free testosterone(FT), estradiol(E₂), complement C3, immunoglobulin IgG and IgM levels of the three groups were observed before and after treatment, and the clinical efficacy of the three groups was compared. Results: The treatment group levels of FT lower than Reference group 1 and Reference group 2(P<0.05), the treatment group levels of SHBG and E₂ higher than Reference group 1 and Reference group 2(P<0.05), and the treatment group levels of complement C3, IgG and IgM lower than Reference group 1 and Reference group 2(P<0.05). The treatment group Qol-Acne score higher than Reference group 1 and Reference group 2(P<0.05), the treatment group GAGS score lower than Reference group 1 and Reference group 2(P<0.05), and the treatment group total effective rate(93.55%) higher Reference group 1(77.42%) and Reference group 2(64.52%) (P<0.05). Conclusion: Aminolevulinic acid photodynamic combined with Yiqing Tablets in the treatment of patients with moderate to severe acne can regulate the patient''s endocrine, improve the level of sex hormones and immune status, relieve the symptoms of acne, improve the quality of life and clinical efficacy.