曲马多代谢相关基因多态性研究进展

盐酸曲马多是临床中常用的弱阿片类药物,用于治疗中度疼痛,其镇痛效果介于弱罂粟碱和吗啡之间,临床中用于术后疼痛、牙痛、和其他疼痛,镇痛效果明显,安全性好。但是由于曲马多各基因型对其药物代谢行为的影响,在临床使用中,曲马多的镇痛效果和不良反应个体差异大。为了研究对比不同种族之间曲马多代谢等位基因的分布情况,作者通过检索,对不同的人种CYP2D6的不同活性,不同人种决定该酶活性的等位基因频率,不同基因型对曲马多代谢行为的影响进行综述。

Advanced Research on Tramadol's Polymorphism

Tramadol hydrochloride is a weak opioids commonly used in clinical for the treatment of moderate pain. The analgesic effect of killing pain is between papaverine and morphine used for postoperative pain, dental pain, and other pain, town pain with good security. However, due to the impact of genotypes, tramadol metabolic behavior of its drugs, analgesia effect and adverse reactions have individual differences in clinical. In order to study the different alleles distribution of different ethnic for tramadol metabolism, the author retrieved different CYP2D6 activity against different races and different ethnic decided enzyme activity allele frequencies of different genotypes on song affect the metabolic behavior of tramadol.