文拉法辛与舍曲林治疗老年性抑郁症的效果及对认知功能的影响

目的:探讨文拉法辛与舍曲林治疗老年性抑郁症的效果及对认知功能的影响。方法:收集我院2012年6月到2014年1月收治的老年性抑郁症患者80例,按照随机数字表法分为观察组和对照组,每组40例,观察组给予盐酸文拉法辛胶囊、对照组给予舍曲林治疗。应用相应量表评价两组患者抑郁症和认知功能变化情况,并记录不良事件发生率。结果:观察组治疗有效率为90.0%,对照组为82.5%,差异无统计学意义(P0.05),治疗后观察组HAMD评分优于对照组,差异具有统计学意义(P0.05),两组治疗后与治疗前相比差异均具有显著统计学意义(P0.05)。治疗前Ra、Cc、Rc、Re、Rf、Rpe、n Rpe指标在两组间差异无统计学意义(P0.05),治疗后观察组优于对照组,差异有统计学意义(P0.05);治疗后两组不良事件发生率差异无统计学意义(P0.05),且经过对症处理均好转。结论:文拉法辛与舍曲林对老年患者抑郁症症状和认知功能改善均有一定的效果,但文拉法辛的治疗效果较舍曲林好,并且安全可靠,临床可以优先选择文拉法辛治疗。

Efficacy of Venlafaxine and Sertraline on Elderly Depression

Objective:To investigate the efficacy of venlafaxine and sertraline on elderly patients with depression and their influence on the cognitive function of the patients.Methods:A total of 80 elderly patients with depression, who were admitted to Nanning Fifth People''s Hospital of Guangxi Province from June 2012 to January 2014, were collected and randomly divided into observation group(n=40) and control group(n=40). The observation group was treated with hydrochloric venlafaxine capsule, while the control group, with sertraline. The changes of depression and cognitive function of two groups were evaluated by the appropriate scale; the incidence of adverse events were recorded.Results:The effective rate in observation group was 90.0%and that in control group was 82.5%, the difference was not statistically significant (P>0.05). HAMD score of observation group was better than that of control group after treatment (P<0.05). There was significantly statistical difference in HAMD score between before and after treatment of two groups (P<0.05). There was no statistical difference in Ra, Cc, Rc, Re, Rf, Rpe, nRpe between the two groups before treatment (P>0.05), but after treatment, observation group was better than control group, and the differences were statistically significant (P<0.05). There was no statistical difference in the incidence of adverse events between the two groups after treatment (P>0.05), which were relieved after symptomatic treatment.Conclusion:Both venlafaxine and sertraline can improve the depression and cognitive function of elderly patients with depression, but the efficacy of venlafaxine is better than that of sertraline, with safety and reliability, which is preferred in the clinical treatment.