女性冠心病患者的危险因素分析及与冠脉病变严重程度的关系

目的:了解女性冠心病患者的危险因素及与冠脉病变严重程度的关系。方法:随机选取本院2012年至2014年心血管科住院治疗的疑似冠心病女性患者150例,经冠脉造影确诊冠心病患者105例,非冠心病患者45例。对患者的临床资料和冠脉病变严重程度进行单因素和多因素分析。结果:冠心病患者高血压与糖尿病百分比、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)及纤维蛋白原水平均高于非冠心病患者,而高密度脂蛋白(HDL-C)和血红蛋白水平均低于非冠心病患者(P0.05);年龄、高血压与糖尿病百分比、血脂上升百分比(高TC、高TG、低HDL-C、高LDL-C)、高尿酸百分比和纤维蛋白原水平均随冠状动脉病变支数及Gensini积分的增加而增加(P0.05);多因素分析发现女性冠心病的影响因素分别为高LDL-C、糖尿病、低HDL-C、TG和高血压,其中高LDL-C的影响最为显著(P0.05)。结论:高血压、糖尿病史、血脂水平为女性冠心病的影响因素,其中高LDL-C的影响最显著,各影响因素均与冠脉病变程度紧密相关。

Analysis of Risk Factors of Coronary Heart Disease in Female Patients and Their Correlation with the Severity of Coronary Artery Lesions

Objective:To understand the risk factors of coronary heart disease for female patients and their correlation with the severity of coronary artery lesions.Methods:150 female patients who were suspected the coronary heart disease were selected from the cardiovascular department in our hospital from 2012 to 2014, among which 105 patients were diagnosed as the coronary heart disease by coronary angiography method and another 45 patients were non-coronary heart disease. Then the clinical indexes and severity of coronary artery lesions of patients were analyzed by both the single factor analysis and the multiple factor analysis.Results:The incidence of hypertension and diabetes mellitus, levels of triglyceride(TG), total cholesterol(TC), low density lipoprotein (LDL-C) and fibrinogen in patients with coronary heart disease were higher than non-coronary heart disease, while the levels of high density lipoprotein (HDL-C) and hemoglobin were lower than non-coronary heart disease (P<0.05). The age, the incidence of hypertension, the diabetes mellitus, the high level of TC and TG, the low level of HDL-C, the high level of LDL-C and the uric acid and the level of fibrinogen increased alone with the coronary artery lesion grade and Gensini grade. Multiple factor analysis showed that the risk factors of coronary heart disease for female patients were the LDL-C, diabetes mellitus, HDL-C, TG and hypertension, and LDL-C was the highest one.Conclusion:Hypertension, diabetes mellitus and levels of blood lipid are the risk factors of coronary heart disease for female patients, especially the high level of LDL-C, and the above factors were closely correlated with the severity of coronary artery lesions.