丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗重症手足口病患儿的临床研究

目的:探讨丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗重症手足口病(HFMD)患儿的临床效果。方法:选择我院2013年1月至2014年1月收治的重症HFMD患儿80例,按随机数字表法平均分为两组,研究组及对照组各40例。对照组患者在常规治疗基础上给予甲泼尼龙琥珀酸钠治疗,研究组患者给予丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗,比较两组患儿治疗疗效,发热、疱疹、神经系统受累症状消退时间及住院时间。结果:研究组患儿治疗总有效率为97.5%,明显高于对照组87.5%,比较差异具有统计学意义(x2=3.85,P0.05)。研究组患儿发热消退时间、疱疹消退时间、神经系统受累症状消退时间及住院时间均明显短于对照组,比较差异具有统计学意义(均P0.05)。结论:丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗重症HFMD患儿疗效显著,可有效改善患儿临床症状,值得临床推广应用。

Clinical Study of Gamma Globulin Combined with Methylprednisolone SodiumSuccinate Injection in Treatment of Children with Severe Hand, Foot and Mouth Disease

Objective:To investigate the clinical effect of gamma globulin combined with methylprednisolone sodium succinate injection in treatment of children with severe hand foot and mouth disease (HFMD).Methods:80 cases of children with severe HFMD who were treated in our hospital from January 2013 to January 2014, they were randomly divided into two groups according to the number table method, the study group and the control group with 40 cases in each group. The control group was treated with methylprednisolone sodium succinate injection on the basis of conventional therapy, while the study group was treated with gamma globulin combined with methylprednisolone sodium succinate injection, then compared the curative effect, fever subside time, herpes subside time, nervous system involvement symptoms subside time and hospitalization time between two groups.Results:The total effective rate of study group was 97.5%, significantly higher than 87.5% in the control group, the difference was statistically significant (X2=3.85, P<0.05). Fever subsided time, herpes subsided time, nervous system involvement symptoms subside time and hospitalization time of study group were significantly shorter than the control group, the differences were statistically significant(all P<0.05).Conclusion:Gamma globulin combined with methylprednisolone sodium succinate injection has an obvious curative effect in treatment of children with severe HFMD, which can effectively improve the clinical symptoms and it is worth applying to the clinical field.