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地西泮和戊巴比妥钠对两种小鼠镇静催眠作用强度的观察
引用本文:朱坤杰,?? 冯淑怡 ?? 孙建宁.地西泮和戊巴比妥钠对两种小鼠镇静催眠作用强度的观察[J].现代生物医学进展,2006,6(8):44-45.
作者姓名:朱坤杰  ?? 冯淑怡 ?? 孙建宁
作者单位:1. 北京中医药大学,北京,100102;齐齐哈尔医学院,黑龙江,齐齐哈尔,161042
2. 北京中医药大学,北京,100102
摘    要:目的:观察地西泮和戊巴比妥纳对不同种属小鼠自主活动和睡眠效应的影响,为筛选影响中枢神经系统功能的药物提供可参考的选择动物的依据。方法:分别取昆明种和ICR小鼠各40只,设对照组和地西泮给药组,每组20只,给药组ig地西泮4mg/kg,对照组给生理盐水,连续3天,末次给药后45分钟测定小鼠自主活动。另取两种小鼠各20只,分别ip戊巴比妥钠50mg/kg,观察两种小鼠的睡眠情况,记录潜伏期和睡眠时间。结果:ICR小鼠ig地西泮后,表现明显的镇静作用,自主活动的次数和对照组比较明显减少,P〈0.01;而昆明种小鼠给相同剂量的地西泮,小鼠自主活动的次数减少不明显,P〉0.05。昆明种和ICR小鼠同样ip阈上剂量的戊巴比妥钠,两者在睡眠潜伏期上无明显差异,但在睡眠时间上,则ICR小鼠的睡眠时间明显长于昆明种小鼠,P〈0.01。结论:ICR小鼠对中枢抑制药的反应性更好,适合于这类药物的筛选,尤其对作用相对较弱的中药制剂,可能提高筛选的阳性率。

关 键 词:戊巴比妥钠  地西泮  镇静催眠作用  昆明种小鼠  ICR小鼠
收稿时间:2006-06-10
修稿时间:2006-07-16

Observation on sedation and hypnosis action of diazepam and pentobarbital on two kinds of mice
ZHUKun- j ie,FENG Shu- yi,SUN Jian- ning.Observation on sedation and hypnosis action of diazepam and pentobarbital on two kinds of mice[J].Progress in Modern Biomedicine,2006,6(8):44-45.
Authors:ZHUKun- j ie  FENG Shu- yi  SUN Jian- ning
Abstract:Objective: To study the influence of sedative hypnotics on autonomic activities and sleep effects in different kinds of mice,and to provide reference of choosing animal for studying medicine influencing neurological function.Methods: After ig diazepam 4mg/kg/day for 3 days,autonomic activities 45minafter the final administration were detected.After IP pentobarbital 50mg/kg,the latent period of sleep and duration were recorded.Results: At the same dose 4mg/kg,diazepam showed obvious sedation in ICR mice,comparing with control group,the automatic activities decreased(P<0.05).But in Kunming mice,the sedation was not be found at the same dose(P>0.05).In another observation,administration of 50mg/kg pentobarbital can obviously prolong sleep duration of ICR mice,comparing with that of Kunming mice(P<0.01).Conclusions: The reaction of ICR mice to central depressant is better,which is suitable to screen medicine depressing neurological function and could raise the positive rate of Chinese pharmaceutics with relative weak effect.
Keywords:Pentobarbital  Diazepam  Sedation and hypnosis action  ICR mice  Kunming mice
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