NT-pro BNP 及D-二聚体水平变化对急性缺血性脑卒中患者预后的影响

目的:探讨急性缺血性脑卒中患者血浆B型脑钠肽前体(NT-proBNP)和D-二聚体水平与病情严重程度的关系。方法:选取2013年6月-2015年6月在我院接受治疗的急性缺血性脑卒中患者81例作为研究对象,另选取同期在我院接受健康体检的志愿者53例作为对照组。检测并比较两组血浆NT-proBNP及D-二聚体水平。结果:急性脑卒中患者血浆NT-proBNP与D-二聚体水平均显著高于对照组,差异具有统计学意义(P0.05)。大面积梗死的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于非大面积梗死患者,差异具有统计学意义(P0.05);NIHSS评分10的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于NIHSS评分≤10的患者,差异具有统计学意义(P0.05);有意识障碍的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于无意识障碍者,差异具有统计学意义(P0.05);随访结局为死亡的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于存活者,差异具有统计学意义(P0.05)。结论:NT-proBNP及D-二聚体水平可以反映急性缺血性脑卒中患者的病情,对脑卒中患者的病情评估及预后判断具有参考价值。

Effects of NT-proBNP and D-dimer Levels on Prognosis of Acute Ischemic Infarction

Objective:To investigate the relationship between plasma levels of B-type natriuretic peptide precursor (NT-proBNP) and D-dimer with acute ischemic stroke.Methods:81 cases who were diagnosed with the acute ischenic stroke in our hospital from June 2013 to June 2015 were selected as the research objects, and another 53 healthy volunteers were selected as the control group. Then the plasma levels of NT-proBNP and D-dimer were detected and compared between the two groups.Results:The NT-proBNP and D-dimer levels in the stroke group were higher than those of the control group, and the differences were statistically significant (P<0.05). The levels of NT-proBNP and D-dimer in the patients with massive area infarction were higher than those of the patients with non-massive area infarction, and the differences were statistically significant (P<0.05); The levels of NT-proBNP and D-dimer in the patients with conscious disturbance were higher than those of the patients with non-conscious disturbance, and the differences were statistically significant (P<0.05); The levels of NT-proBNP and D-dimer in the patients with the NIHSS score>10 were higher than those of the patients with the NIHSS score<10, and the difference was statistically significant (P<0.05).Conclusion:The levels of NT-proBNP and D-dimer can reflect the severity of acute ischemic stroke, which could provide a reference for the evaluation and prognosis of disease.