2 型糖尿病合并高血压患者发生心房颤动的相关因素分析

目的:探讨2型糖尿病合并高血压住院患者发生心房颤动的相关因素。方法:选取我院收治的2型糖尿病合并高血压发生心房颤动的患者112例为研究对象(房颤组,n=112例),同期选取与房颤组年龄及性别相匹配的未发生房颤的2型糖尿病合并高血压患者150例为对照组(n=150例),比较两组患者的一般临床资料、实验室检查指标等的差异,用Logistic回归方程分析患者并发房颤的相关因素。结果:与对照组比较,房颤组患者收缩压(SBP)较高,高血压比例高、服用ACEI/ARB类药物偏低(P0.05)、左室射血分数(LVEF)偏低(P0.05)、左房内径(LAD)长(P0.05)、甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、血肌酐(Scr)、B型脑钠肽(BNP)、高敏C反应蛋白(hs-CRP)、尿酸均较高(P0.05);多因素Logistic回归方程分析提示:LAD、HbA1c、BNP、hs-CRP、尿酸是患者并发房颤的独立危险因素(P0.05),而服用ACEI/ARB类药物为保护性因素。结论:LAD、HbA1c、BNP、hs-CRP、尿酸均可能是2型糖尿病合并高血压患者发生心房颤动的独立危险因素。

Related Factors Analysis of Atrial Fibrillation in Type 2 Diabetes Mellitus Patients with Hypertension*

Objective:To investigate the related factors of atrial fibrillation for hospitalized patients with type 2 diabetes mellitus and hypertension ertension.Methods:112 cases of atrial fibrillation patients combined with type 2 diabetes mellitus and hypertension were taken as the research objects, and, named as atrial fibrillation group (n=112). At the same time, 150 cases of patients with type 2 diabetes mellitus and hypertension whose age and gender were matched with the atrial fibrillation group but had no atrial fibrillation were selected as control group (n=150). The clinical data and laboratory examination indexes were compared, and factors associated with atrial fibrillation complication were analyzed by using Logistic regression equation.Results:Compared with control group, patients in atrial fibrillation group had high systolic blood pressure (SBP), high proportion of hypertension, low proportion of taking ACEI/ARB drugs (P<0.05), low left ventricular ejection fraction (LVEF) (P<0.05), long left atrial diameter (LAD) (P<0.05), and high levels of triglycerides (TC), low-density lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c), serumcreatinine (Scr), b-type brain natriuretic peptide (BNP), high-sensitivity c-reactive protein (hs CRP) and uric acid (P<0.05). Multiariable Logistic regression equation analysis showed that LAD,HbA1c, BNP, hs CRP and uric acid were independent risk factors of patients complicated with atrial fibrillation (P<0.05), while taking ACEI/ARB drugs was protective factors.Conclusion:LAD, HbA1c, BNP, hs CRP and uric acid may be independent risk factors for patients with type 2 diabetes mellitus and hypertension complicated with atrial fibrillation.