坎地沙坦酯与银杏注射液对慢性肺心病急性加重期患者肺动脉压的影响

目的:探究坎地沙坦酯联合银杏注射液对慢性肺心病急性加重期患者肺动脉压、血管内皮生长因子水平及临床疗效的影响。方法:收集我院诊治的慢性肺心病急性加重期患者134例,随机分为对照组和试验组,每组67例。对照组患者口服坎地沙坦酯片治疗,试验组患者在对照组基础上联合静脉滴注银杏注射液治疗。观察并比较两组患者的临床疗效、治疗前后的肺动脉压及血管内皮生长因子水平变化情况。结果:治疗后,两组肺动脉压及血管内皮生长因子水平均较治疗前显著降低(P0.05),与对照组相比,试验组患者治疗总有效率较高(P0.05),肺动脉压及血管内皮生长因子水平较低(P0.05)。结论:坎地沙坦酯联合银杏注射液对慢性肺心病急性加重期患者疗效明显,能够有效降低肺动脉压,可能与降低血管内皮生长因子水平有关。

Effect of Candesartan combined with Ginkgo Biloba Injection on the Pulmonary Arterial Pressure of Patients with Cor Pulmonale during Acute Attack

Objective:To investigate the effect of candesartan combined with Ginkgo biloba injection on the pulmonary arterial pressure of patients with Cor pulmonale during acute attack.Methods:134 patients with acute exacerbation of chronic pulmonary heart disease fromour hospital were selected and randomly divided into the control group (67 cases) and the experiment group (67 cases). Both groups were treated by conventional therapy, the control group was treated by Candesartan Cilexetil Tablets, 8 mg each time, once a day; the experiment group was treated on the basis of the control group with intravenous injection of Ginkgo biloba, 20 mL each time, added to the 0.9%Sodium Chloride Injection 200 mL, once a day. 14 days was a course of treatment, a total of a course of treatment. The clinical efficacy, pulmonary arterial pressure and vascular endothelial growth factor were compared after two weeks between two groups.Results:Compared with the control group, the total effective rate in the experiment group was higher (P<0.05). Compared with before treatment, the pulmonary arterial pressure and vascular endothelial growth factor were significantly lower in both groups after treatment(P<0.05). Compared with the control group, the pulmonary arterial pressure and vascular endothelial growth factor were lower in the experiment group (P<0.05).Conclusion:Candesartan cilexetil combined with Ginkgo injection had obvious curative effect on patients with Cor pulmonale during acute attack, which might be related to the decrease of vascular endothelial growth factor level.