右美托咪定与咪达唑仑对前列腺电切术患者术后认知功能的影响

目的:分析右美托咪定与咪达唑仑对前列腺电切术(TURP)患者认知功能的影响。方法:选择2013年5月-2015年5月在我院接受TURP治疗的良性前列腺增生患者73例作为研究对象。根据麻醉方法不同,将所选患者分为右美托咪定组和咪达唑仑组,分别采用右美托咪定和咪达唑仑麻醉。观察并比较不同时间点两组患者的心率(HR)及平均动脉压(MAP)的变化情况。应用精神状态量表(MMSE)评估两组患者手术前后的认知功能。结果:两组患者术前HR及MAP比较,差异均无统计学意义(P0.05);两组患者手术不同时间点HR、MAP均显著低于术前,且右美托咪定组低于咪达唑仑组,差异具有统计学意义(P0.05);两组患者术前MMSE评分比较,差异无统计学意义(P0.05);两组患者术后MMSE评分均低于术前,且右美托咪定组低于咪达唑仑组,差异均具有统计学意义(P0.05);右美托咪定组术中寒战发生率显著低于咪达唑仑组,差异具有统计学意义(P0.05)。结论:右美托咪定与咪达唑仑对TURP患者均会造成早期认知功能障碍,但右美托咪定的影响较小,患者生命体征较平稳,值得临床推广应用。

Effects of Dexmedetomidine and Midazolam on the Early Postoperative Cognitive Function of Patients with TURP

Objective:To study the effects of dexmedetomidine and midazolam on the postoperative cognitive function of patients with transurethral resection of prostate (TURP).Methods:73 patients with benign prostatic hyperplasia who were treated in our hospital from May 2013 to May 2015 were selected as the research objects. According to the different anesthesia methods, the selected patients were divided into the dexmedetomidine group and the midazolam group, that treated with dexmedetomidine and midazolam, respectively. Then the changes of heart rate (HR) and mean arterial pressure (MAP) in the two groups were observed and compared before and after the treatment. The cognitive function of patients was assessed by the MMSE.Results:There was no statistically significant difference about the HR and MAP before operation (P>0.05); At different time points, the HR and MAP in the two groups were significantly lower than before operation, and the dexmedetomidine group was lower than that of the midazolam group, and the difference was statistically significant (P<0.05); There was no statistically significant difference about the MMSE score in the two groups before operation (P>0.05); At different time points, the MMSE score in the two groups were significantly lower than before operation, and the dexmedetomidine group was lower than that of the midazolam group, and the difference was statistically significant (P<0.05); The incidence of chills in the dexmedetomidine group was lower than that of the midazolam group, and the difference was statistically significant (P<0.05).Conclusion:Dexmedetomidine and midazolamcould cause the cognitive dysfunction of patients with TURP, but the effect of dexmedetomidine was smaller, and the vital signs were more stable, which is worthy of clinical application.