氨氯地平、比索洛尔对高血压合并心绞痛患者CAP及IMT 的影响

目的:比较氨氯地平、比索洛尔对高血压合并心绞痛患者中心动脉压(central artery pressure,CAP)及颈动脉内中膜厚度(intima-media thickness,IMT)的影响。方法:选择我院2013年8月-2014年9月收治的高血压合并心绞痛患者76例,随机分为观察组和对照组,各38例。观察组给予氨氯地平5 mg/d,对照组给予比索洛尔2.5 mg/d,疗程均为1年。测定并对比两组治疗前后血压、CAP、IMT变化情况以及心绞痛的治疗效果。结果:观察组治疗后CAP收缩压、舒张压、IMT分别为(130.36±5.09)mm Hg、(73.38±5.76)mm Hg、(0.89±0.08)mm,均明显低于对照组的(144.82±6.54)mm Hg、(84.89±6.14)mm Hg、(1.01±0.12)mm,差异均有统计学意义(P0.05)。观察组治疗总有效率为89.47%,高于对照组的76.32%,但差异无统计学意义(P0.05)。结论:氨氯地平与比索洛尔治疗高血压合并心绞痛的临床疗效相当,但氨氯地平在降低高血压合并心绞痛患者CAP、IMT方面的效果优于比索洛尔。

Effect of Amlodipine and Bisoprolol on the CAP and IMT of Hypertensive Patients combined with Angina Pectoris

Objective:To compare the effect of amlodipine and bisoprolol on the central artery pressure (CAP) and carotid artery intima-media thickness (IMT) of hypertensive patients combined with angina pectoris.Methods:76 cases of hypertensive patients combined with angina pectoris admitted in our hospital fromAugust 2013 to September 2014 were randomly divided into the observation group and the control group, 38 cases in each group. The observation group was given amlodipine 5 mg/d, while the control group was given bisoprolol 2.5 mg/d for 1 years. The changes of blood pressure, CAP and IMT before and after treatment in two groups were measured and compared, and the therapeutic effect of angina pectoris was measured and compared.Results:In the observation group after treatment, the systolic blood pressure, diastolic blood pressure and IMT were (130.36 ± 5.09) mmHg (73.38± 5.76) mmHg (0.89± 0.08) mm, which were lower than those of the control group (144.82 ± 6.54) mmHg, (84.89 ± 6.14) mmHg and (1.01± 0.12) mm, the differences were statistically significant (P<0.05). And the total efficiency of observation group was 89.47%, which was higher than that of the control group(76.32%), but no statistically significant difference was found between two groups(P>0.05).Conclusion:The clinical efficacy of amlodipine was equal to bisoprolol in the treatment of hypertensive patients combined with angina pectoris, but it could more effectively reduce the CAP and IMT than bisoprolol.