脂蛋白(a)与动脉粥样硬化及脑梗死的研究进展

脂蛋白(a)是由载脂蛋白(a)和低密度脂蛋白构成的。脂蛋白(a)不随血浆中同型半胱氨酸、载脂蛋白A、高密度脂蛋白的变化而变化,是一种相对独立的脂蛋白。脂蛋白(a)的合成过程主要是在肝脏中完成的,脂蛋白(a)可以抑制NO介导的血管舒张,破坏血管壁中促凝与抗凝因子的平衡,参与动脉粥样硬化斑块的形成。动脉粥样硬化是脑梗死最基本的病因之一,在临床工作中我们应当重视脂蛋白(a)与脑梗死的关系,我们可以通过测定血清中脂蛋白(a)的水平来预测脑梗死的患病风险,尤其能对病变损害程度重,病变累及范围广的脑梗死的发生提出预警。高水平的血浆脂蛋白(a)是脑梗死及动脉粥样硬化的独立危险因素,本文就脂蛋白(a)与动脉粥样硬化及脑梗死研究中的进展做一综述,为脑梗死的预防提供参考和研究依据。

Advances in Lipoprotein (a) and Atherosclerosis and Cerebral Infarction

Lipoprotein (a) is composed of apolipoprotein (a) and low density lipoprotein. Lipoprotein (a) does not change with plasma homocysteine, apolipoprotein A, and high-density lipoprotein. It is a relatively independent protein. Lipoprotein (a) during the synthesis is mainly completed in liver. Lipoprotein (a) can inhibit NO-mediated vasodilation, destroying the balance of the procoagulant and anticoagulant factors in the vessel wall. Atherosclerosis is one of the fundamental causes of cerebral infarction. In the clinical work, the relationship between lipoprotein (a) and cerebral infarction should be taken seriously. We can also by measuring serum lipoprotein (a) levels to predict the risk of cerebral infarction. In particular, We can also issue alert for severe cerebral infarction. High level of plasma lipoprotein (a) is an independent risk factor for cerebral infarction and arterial atherosclerosis. In this paper, new progress about lipoprotein (a) and cerebral infarction will be reviewed, so as to provide valuable references and research based for prevention of cerebral infarction.