血清IL-6 及S-100B 水平对颅脑损伤严重程度和预后评估的临床意义

目的:探讨血清IL-6及S-100B水平变化对颅脑损伤患者病情程度及预后评估的临床价值。方法:选择我院2013年7月~2015年7月收治的颅脑损伤患者100例为研究对象,依据格拉斯哥昏迷评分(GCS)将患者分为特重型损伤组、重型损伤组、中型损伤组和轻型损伤组,每组25例。另选择同期在我院接受体检的25位健康志愿者作为对照组。采用酶联免疫吸附法检测各组研究对象不同时间点血清IL-6及S-100B水平,并分析IL-6及S-100B水平变化与颅脑损伤程度及预后的关系。结果:颅脑损伤后第1、3、5、7、14天患者血清IL-6及S-100B水平均显著高于对照组,差异具有统计学意义(P0.05)。在相同检测时间,损伤程度越重的患者其血清IL-6及S-100B水平越高,差异具有统计学意义(P0.05);相同损伤程度颅脑损伤患者随着损伤时间延长,其血清IL-6水平越高,差异具有统计学意义(P0.05);相同损伤程度颅脑损伤患者血清S-100B水平在损伤后第1天开始上升,第3天达到高峰,第5天开始下降,差异具有统计学意义(P0.05)。颅脑损伤患者血清IL-6和S-100B水平与格拉斯哥预后评分(GOS)和格拉斯哥昏迷评分(GCS)呈负相关(rIL-6=-0.812、-0.770,rS-100B=-0.767、-0.831,P0.05),与颅脑损伤程度呈正相关关系(r=0.776、0.791,P0.05)。结论:血清IL-6和S-100B水平与颅脑损伤患者病情严重程度和预后相关,对颅脑损伤程度的临床诊断及预后评估具有重要参考价值。

Clinical Value of SerumIL-6 and S-100B Levels for the Evaluation of Severity and Prognosis of Patients with Craniocerebral Injury

Objective:To investigate the clinical value of serum IL-6 and S-100B in the evaluation of severity and prognosis of patients with craniocerebral injury.Methods:100 cases with craniocerebral injury who were treated in our hospital fromJuly 2013 to July 2015 were selected and according to the Glasgow Coma Scale (GCS), the patients were divided into the specially severe injury group, the severe injury group, the mediuminjury group and the slight injury group with 25 cases in each group. And another 25 healthy volunteers who received the medical examination in our hospital were selected as the control group. Then the serum levels of S-100B and IL-6 were detected by the enzyme linked immunosorbent assay, and the relationship between the serumS-100B and IL-6 levels and the severity and prognosis of craniocerebral injury were analyzed.Results:The serum levels of IL-6 and S-100B of craniocerebral injury patients were significantly higher than those of the patients in control group (P<0.05). At the same time, the levels of serumIL-6 and S-100B in patients with different degrees of injury were different, the levels of serum IL-6 and S-100B were higher, and the difference was statistically significant (P<0.05); The level of serum IL-6 in patients with the same degree of injury was different, and the levels of serum IL-6 increased with the time of injury, and the difference was statistically significant (P<0.05); The level of serumS-100B in patients with the same degree of injury was different, and the level of serum was increased at first days, and reached the peak at third days, and the difference was statistically significant (P<0.05). The levels of IL-6 and S-100B were all negatively correlated with GOS and GCS (P<0. 05), and positively correlated with the severity of craniocerebral injury (P<0.05).Conclusion:The levels of serum IL-6 and S-100B were closely related to the severity and prognosis of patients with craniocerebral injury.