结核休眠菌与巨噬细胞自噬

结核休眠菌是残存于人体巨噬细胞内处于代谢静止期的极微量结核分枝杆菌(MTB),了解其生物学特性和相关作用机制对MTB潜伏感染新靶点药物的研究具有重要意义。巨噬细胞作为机体固有免疫和适应性免疫的重要组成部分,是清除胞内感染的MTB的首要屏障。巨噬细胞可以通过自噬途径清除MTB,而处于休眠状态的MTB可以逃避巨噬细胞的杀伤而持续存在。此外,目前有关休眠菌如何逃逸巨噬细胞自噬的具体机制也并不十分明确,本文则对休眠菌及其与巨噬细胞自噬相关研究的最新进展作一综述。

Dormant Tubercle Bacilli and Autophagy in Macrophage

Dormant Tubercle bacillus is the trace amounts of Mycobacterium tuberculosis(MTB) residing in the human macrophages in the metabolic stationary phase, and it is of great significance to understand the biological characteristics and the relevant mechanism of LTBI (Latent Tuberculosis Infection) for the new drug discovery. Macrophage, as an important component of the host innate and adaptive immune system, is the first barrier to clear intracellular MTB. First, it can be eradicated by macrophages in autophagy-dependent process; then, the dormant tubercle bacillus can evade the autophagy in macrophage and persist, of which the relevant mechanismis not very clear. Then, we would make a review of the recent research on the relationship between dormant Tubeicle bacillus and the autophagy in macrophage.