血清AQP-4 抗体水平与急性期视神经脊髓炎患者临床特征的关系

目的:探究血清水通道蛋白4(AQP-4)与急性期视神经脊髓炎(NOM)患者临床特征的相关性,为临床上预防急性期NOM患者提供参考。方法:选取2009年1月至2016年1月来我院治疗的63例NOM患者,另选取20例健康体检者为对照,采用酶联免疫吸附试验测定所有受试者血清中AQP-4抗体浓度,分析AQP-4抗体水平与NOM患者临床特征的关系。结果:NOM患者血清AQP-4抗体的浓度为(425.45±18.34)ng/ml,阳性检出率为80.73%。健康体检者血清AQP-4抗体的浓度为(112.34±15.27)ng/ml。Spearman相关性分析发现,血清AQP-4抗体水平与EDSS评分、大脑磁共振成像病灶数及脊髓受累节段数均呈正相关(r=0.383,P=0.001;r=0.315,P=0.007;r=0.297,P=0.012);与至下一次复发间隔时间之间无明显相关性(r=-0.096,P=0.332)。结论:AQP-4抗体水平与NOM疾患者临床症状以及病程严重程度有一定的相关性,但AQP-4作为预测疾病复发的检测蛋白意义不大。

Relationship Between SerumAQP-4 Antibody Levels and Clinical Features in Patients with Neuro-Optic Myelitis at Acute Stage

Objective:To explore the relationship between serum AQP-4 antibody levels and clinical features in patients with neuro-optic myelitis(NOM) at acute stage, provide reference for clinical prevention of NOMat acute stage.Methods:63 cases of patients with NOM from January 2009 to January 2016 in our hospital were selected,and another 20 cases of healthy persons were selected as control. Enzyme linked immunosorbent assay was used to determine the concentration of AQP-4 in serum of all subjects, and the relationship between the level of AQP-4 antibody and the clinical features of NOM patients was analyzed.Results:The concentration of serum AQP-4 antibody in NOM patients was (425.45± 18.34) ng/mL, the positive detection rate was 80.73%. The concentration of serum AQP-4 antibody in healthy subjects was (112.34± 15.27) ng/mL. According to the Spearman correlation analysis, there was a positive correlation between the level of serum AQP-4 antibody and EDSS score, the number of lesions in the brain magnetic resonance imaging and the number of the spinal cord (r=0.383, P=0.001; r=0.315, P=0.007; r=0.297, P=0.012), while no significant correlation with the time to the next recurrence(r=-0.096, P=0.332).Conclusion:There was a certain correlation between the level of AQP-4 antibody and the clinical symptoms and the severity of disease in patients with NOM disease, but AQP-4 was not significant in predicting the recurrence of the disease.