家兔低密度脂蛋白胆固醇增高及同步饮磁处理水时动脉内膜病理学变化的比较研究

目的:观察家兔实验性低密度脂蛋白胆固醇(LDL -c)增高及同步饮磁处理水时动脉内膜病理变化的区别,探讨磁处理水对动脉粥样硬化的预防作用。方法:新西兰雄性大白兔随机分为3组即对照组(NG)、模型组(ASG)和预防组(MWG) ,以高脂饲料复制家兔动脉粥样硬化(AS)模型。MWG家兔喂高脂饲料同步饮磁处理水,分阶段检测各组家兔血浆LDL -c含量并观察其主动脉内膜病理学改变。结果:MWG血浆LDL -c含量明显较ASG降低(P <0 .0 1,MWG主动脉内膜脂质沉积及粥样斑块形成面积较ASG减小(P <0 .0 1,内膜增生程度较ASG减轻(P <0 .0 1)。结论:提示磁处理水在家兔实验性高LDL -c血症及AS的预防中起一定作用。

The effect of magnetized water on the experimental hyper LDL-c emia and aortic intimal hyperplasia of rabbits

Objective: To study anti-hyper-low density lipoprotein cholesterol(LDL-c) and anti-atherogenetic effects of magnetized water in cholesterol-fed rabbits. Methods: The hyper LDL-c emia and the atherosclerosis(AS) model of rabbits were copied, feeding them with cholesterol-fed and magnetized water, detecting the amount of LDL-c in blood by stages and observing the aortic intima. Results: The content of plasma LDL-c in the magnetized water-fed group(MWG) were significantly lower(p(0.01) than that in the AS group(ASG); the area of fatty steak and atheromatous plaque in the aortic intima of the former and the degrees of aortic intimal hyperplasia were reduced(p(0.01) significantly in MWG, compared with ASG. Conclusion: The results suggest the possibility that magnetized water plays some role in prevention of the experimental hyper LDL-c emia and AS of rabbits and It(s mechanism were dicussed.