酒石酸布托啡诺对全麻诱导期枸橼酸芬太尼诱发呛咳的影响

目的：探讨布托啡诺对全麻诱导期芬太尼诱发呛咳的影响。方法：将80例ASAⅠ-Ⅱ级患者随机分成两组,布托啡诺组和对照组（每组40例）。麻醉诱导前预注布托啡诺（布托啡诺组）或等量生理盐水（对照组）,5 min后由外周静脉快速注射芬太尼3μg/kg（2 s内）,观察2 min内呛咳反应的发生率,随后给予依托咪酯0.3 mg/kg,顺式阿曲库铵0.15 mg/kg进行气管插管,行机械通气并观测血流动力学变化。结果：布托啡诺组仅有2例患者出现轻中度呛咳（5%）,而对照组有27例（67.5%）出现不同程度的呛咳,其中轻度8例（20.0%）,中度15例（37.5%）,重度为4例（10.0%）。与对照组相比,布托啡诺组血流动力学更为平稳。结论：全麻诱导前5 min预注射布托啡诺可显著抑制芬太尼诱发的呛咳反应,且可减轻插管反应。

Effects of Butorphanol Pretreatment on Fentanyl-induced Cough during General Aneasthesia Induction

Objective： To investigate the effects of pre-induction butorphanol administration on fentanyl-induced cough during aneasthesia induction. Methods： 80 elective surgical patients, scaled I - II by ASA, were randomly divided into two groups. Butor- phanol or equal Volume normal saline was injected through peripheral cannula 5 minutes prior to intravenous administration of 3 μg/kg fentanyl in 2 seconds. The incidence of cough was observed in 2 minutes and hemodynarnics during the procedure were recorded. Results： Only 2 （5 %） patients had mild to moderate cough in pre-treatrnent butorphanol group, while 27 （67.5 %） patients in control group, in which there were 8 mild cases （20.0 %）, 15 moderate （37.5 %） and 4 severe （10.0 %）. Besides, compared with control group, the blood- pressure and heartrate of patients in pre-treatrnent butorphanol group were more stable. Conclusions： Butorphanol pre-treatment 5 min before induction significantly suppresses fentanyl-induced cough and intubation reaction during general aneasthesia induction.