| 葡萄籽原花青素对大鼠烟雾吸入性肺损伤的保护作用 |
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| 引用本文： | 瞿少伊,金发光,高维,孙丹丹.葡萄籽原花青素对大鼠烟雾吸入性肺损伤的保护作用[J].现代生物医学进展,2010,10(2). |
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| 作者姓名： | 瞿少伊 金发光 高维 孙丹丹 |
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| 作者单位： | 1. 第四军医大学唐都医院呼吸科,陕西,西安,710038
2. 第四军医大学唐都医院超声科,陕西,西安,710038 |
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| 基金项目： | 军队十一五攻关项目(08G-102); 陕西省社会攻关课题(2009K01-75) |
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| 摘 要： | 目的:探讨葡萄籽原花青素(grape seed proanthocyanidin extract,GSPE)对大鼠烟雾吸入性肺损伤的保护作用。方法:将48只大鼠随机分为正常对照组、烟雾吸入性肺损伤模型组、GSPE治疗组(500mg/kg),分别于致伤后2、4、12、24h监测动脉血气分析,分批处死大鼠,分别进行肺组织湿/干重测定,制备组织匀浆测超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮合酶(NOS)活性及一氧化氮(NO)、丙二醛(MDA)含量和HE染色。结果:与模型组比较,GSPE治疗组各时间点动脉血氧分压均显著升高(P<0.01),肺组织含水量显著降低(P<0.05),肺组织中SOD活性均明显升高(P<0.01),GSH-Px活性均明显升高(P<0.05),NOS活性及NO、MDA含量均明显降低(P<0.05)。肺组织病理学观察GSPE治疗组较模型组肺间质水肿减轻,炎性细胞浸润减少。结论:GSPE可能通过其显著增加组织的抗氧化能力而对烟雾吸入性肺损伤起到一定保护作用。
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| 关 键 词： | 葡萄籽原花青素 烟雾吸入 急性肺损伤 |
Effect of Grape Seed Proanthocyanidin Extract in Rats with Smoke Inhalation Pulmonary Injury |
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| QU Shao-yi,JIN Fa-guang,Gao Wei,SUN Dan-dan.Effect of Grape Seed Proanthocyanidin Extract in Rats with Smoke Inhalation Pulmonary Injury[J].Progress in Modern Biomedicine,2010,10(2). |
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| Authors: | QU Shao-yi JIN Fa-guang Gao Wei SUN Dan-dan |
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| Institution: | QU Shao-yi1,JIN Fa-guang1,Gao Wei1,SUN Dan-dan2(1 Department of Respiratory Medicine,Tangdu Hospital,the Fourth Military Medical University. 710038,Xi\'an,China,2 Department of ultrasonographic,China) |
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| Abstract: | Objective:To investigate the effect of grape seed proanthocyanidin extract(GSPE) in rats of smoke inhalation pulmonary injury. Methods:Forty-eight healthy male SD rats were randomly divided into three groups:control group(n=8) ,smoke inhalation model group(n=20) and GSPE treatment group(n=20) . After reproducing the smoke inhalation model,GSPE(500mg/kg) was administered intraperitoneal injection to the GSPE group,Arterial blood gas analysis was monitored at 2,4,12 and 24 hours. The rats were sacrificed at d... |
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| Keywords: | Grape seed proanthocyanidin extracts smoke inhalation Acute lung injury |
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