芦荟多糖含量测定及芦荟膏体外透皮吸收的实验研究

目的:研究芦荟膏中各功能成分体外透皮吸收的能力。方法:以Wistar大鼠的背部皮肤为透皮实验原料,每隔一定时间通过分光光度法和高效液相色谱法测定透皮后接收池内芦荟多糖及蒽醌类含量。结果:随着芦荟膏剂量的增加,渗透量逐渐增加,芦荟膏中芦荟多糖、芦荟大黄素、芦荟苷的渗透量随时间延长逐渐增加,但是渗透速率逐渐降低。结论:芦荟膏有较强的体外透皮吸收能力,芦荟膏经皮给药能充分发挥其作用。

Content in Aloe Polysaccharide fromAloe Barbadensis Miller and Transdermal Absorption of Aloe Mastic

Objective:To investiagte the invitro transdermal absorption ability.Methods:Back skin of Wista rats were used as the transdermal experiment material. After transdermal absorption, the contents of aloe polysaccharide and anthraquinones in the reception tank were measured at regular intervals by spectrophotometry and HPLC respectively.Results:With increasing doses of aloe mastic, the amount of infiltration gradually increased.Permeability of aloe polysaccharide, aloe emodin, aloe extract aloin content increased gradually, while the penetration rate decreased.Conclusion:Aloe mastic has a strong ability of invitro transdermal absorption , transderm delivery of aloe mastic could make full use of its function.