| 白介素-32在HBV感染者的变化及其临床意义 |
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| 引用本文： | 许春梅,左维泽,沈兰超.白介素-32在HBV感染者的变化及其临床意义[J].现代生物医学进展,2010,10(2). |
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| 作者姓名： | 许春梅 左维泽 沈兰超 |
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| 作者单位： | 新疆石河子大学医学院,新疆,石河子,832002 |
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| 摘 要： | 目的:探讨乙型肝炎病毒(HBV)感染者血清中白介素-32(IL-32)水平的变化及其临床意义。方法:对100例HBV感染者和30例健康者检测外周血清白细胞介素-32(IL-32)的含量,比较IL-32水平变化的规律,并分析其与临床疾病谱和HBV复制水平的关系。结果:(1)急性乙型肝炎、中度慢性乙型肝炎、重度慢性乙型肝炎患者血清IL-32水平与对照组有显著性差异(P<0.001);轻度慢性乙型肝炎患者血清IL-32水平高于健康对照组,但无统计学意义(P>0.05);急性乙型肝炎、中、重度慢性乙型肝炎患者血清IL-32水平均显著高于轻度慢性乙型肝炎组,且有统计学意义(P<0.001);急性乙型肝炎、重度慢性乙型肝炎患者血清IL-32水平均高于中度慢性乙型肝炎组,有统计学意义(P<0.001);急性乙型肝炎、重度慢性乙型肝炎组之间无明显差异(P>0.05)。(2)HBV感染者HBV-DNA阳性组IL-32水平较阴性组为高,但无差异;高、中、低病毒载量组之间血清IL-32水平也无差异(P>0.05)。(3)慢性乙型肝炎患者不同ALT水平组血清IL-32水平均高于对照组(P<0.05);且低、中、高ALT水平组之间与I...
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| 关 键 词： | HBV感染 白细胞介素-32 |
Clinical significance and changes of serum level of interleukin-32 in patients with chronic hepatitis B virus infection |
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| XU Chun-mei,ZUO Wei-ze,SHEN Lan-chao.Clinical significance and changes of serum level of interleukin-32 in patients with chronic hepatitis B virus infection[J].Progress in Modern Biomedicine,2010,10(2). |
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| Authors: | XU Chun-mei ZUO Wei-ze SHEN Lan-chao |
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| Institution: | XU Chun-mei,ZUO Wei-ze,SHEN Lan-chao(Medical school of Shihezi University,shihezi,832002,China,Department of infection,First Affiliated Hospital,Medical school of Shihezi University,China) |
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| Abstract: | Objective:To investigate the clinical significance and changes of serum level of interleukin-32 in patients with chronic hepatitis B virus infection. Methods:100 patients with chronic HBV-infection were studied. The serum IL-32 level was detected in chronic HBV infected patients and 30 normal controls. The relationship between the changes of serum IL-32 and the clinical spectrum of the disease was analyzed. The serum IL-32 level was also compared among groups based on the serum level of HBV viral load. Resu... |
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| Keywords: | HBV-infections Interleukin-32 |
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