| 生长激素-海藻酸钠-壳聚糖微胶囊促进骨折愈合的组织学研究 |
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| 引用本文： | 张亦军,赛佳明,黄勇,张增方,江晓路.生长激素-海藻酸钠-壳聚糖微胶囊促进骨折愈合的组织学研究[J].现代生物医学进展,2010,10(2). |
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| 作者姓名： | 张亦军 赛佳明 黄勇 张增方 江晓路 |
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| 作者单位： | 1. 青岛市骨伤科医院,山东青岛,266021
2. 中国海洋大学,山东,青岛,266000 |
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| 基金项目： | 青岛市2008年度医药科研指导计划(2008-wszd126)项目 |
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| 摘 要： | 目的:观察生长激素-海藻酸钠-壳聚糖微胶囊促进兔挠骨骨折愈合的作用。方法:实验将新西兰兔80只,在制备新西兰兔右桡骨中段3mm骨缺损模型的基础上,随机分成四组:口服生长激素-海藻酸钠-壳聚糖微胶囊组、皮下注射生长激素组、口服空微胶囊组和生理盐水对照组。实验组口服生长激素-海藻酸钠-壳聚糖微胶囊和皮下注射生长激素,对照组口服空微胶囊。并于术后9、17、30、42d定期HE染色和地衣红染色观察各组的骨折愈合情况。结果:本实验HE染色结果表明,由于在骨缺损部位成纤维细胞产生的大量胶原纤维为基质,形成透明软骨及成骨细胞,骨小梁生长的基础,连接骨痂形成和骨髓腔贯通。而观察到生长激素微胶囊组各期提前生长及改建提前的形态。地衣红染色图像结果分析及直方图的分析表明:生长激素微胶囊组胶原纤维产生促进骨小梁提前形成,进而骨折处骨性骨痂的提前愈合和髓腔的提前贯通。结论:生长激素-海藻酸钠-壳聚糖微胶囊口服能促进骨折修复愈合。
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| 关 键 词： | 生长激素 海藻酸钠 壳聚糖 微胶囊 骨折 骨修复 |
Study on Growth Hormone-Chitosan-Alginate Microcapsules in Promoting Fracture Healing |
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| ZHANG Yi-jun,SAI Jia-ming,HUANG Yong,ZHANG Zeng- fang,JIANG Xiao-lu.Study on Growth Hormone-Chitosan-Alginate Microcapsules in Promoting Fracture Healing[J].Progress in Modern Biomedicine,2010,10(2). |
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| Authors: | ZHANG Yi-jun SAI Jia-ming HUANG Yong ZHANG Zeng- fang JIANG Xiao-lu |
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| Institution: | ZHANG Yi-jun1,SAI Jia-ming1,HUANG Yong1,ZHANG Zeng-fang1,JIANG Xiao-lu2(1 Qingdao Orthopedics , Traumatology Hospital,Qingdao 266021,China,2 Chinese ocean university,China) |
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| Abstract: | Objective:To study the effects of GH-Chitosan-Alginate Microcapsules on fracture healing in Newzealand rabbits. Method:Eighty healthy Newzealand rabbits were made into models with 3mm bone defect in middle segment of radius. They were randomly divided into four groups:GH-Chitosan-Alginate microcapsules group treated orally with GH-Chitosan-Alginate microcapsules,the GH injection group injected with GH,the blank microcapsules group treated orally with blank microcapsules,the control group treated orally with... |
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| Keywords: | Growth Hormone(GH) Chitosan Alginate Microcapsules fracture bone repair |
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