高血压脑出血患者高迁移率族蛋白-1、铁蛋白、血管内皮素的表达及其临床意义

目的:探讨高血压脑出血患者高迁移率族蛋白-1(HMGB-1)、铁蛋白(SF)、血管内皮素(ET-1)的表达水平及其临床意义。方法:选择泰山医学院附属聊城市第二人民医院2014年6月至2017年12月收治的高血压脑出血患者96例作为研究组,另选择同期于该院体检的健康志愿者80例作为对照组。根据神经缺损程度将研究组分为轻度组28例、中度组43例和重度组25例,根据预后结果将研究组分为预后良好组62例和预后不良组34例。比较研究组和对照组、不同神经缺损程度及不同预后患者血清HMGB-1、SF、ET-1水平,并分析高血压脑出血患者血清HMGB-1、SF、ET-1水平与美国国立研究院急性脑卒中量表(NIHSS)的相关性。结果:研究组血清HMGB-1、SF、ET-1水平均显著高于对照组(P0.05)。研究组患者神经缺损程度越严重,血清HMGB-1、SF、ET-1水平越高(P0.05)。预后不良组患者血清HMGB-1、SF、ET-1水平高于预后良好组(P0.05)。经Pearson相关性分析显示,高血压脑出血患者血清HMGB-1、SF、ET-1水平与NIHSS评分均呈正相关(P0.05)。结论:高血压脑出血患者血清HMGB-1、SF、ET-1水平与神经缺损程度、预后密切相关,三指标水平越高,患者病情越严重,且预后越差,检测上述指标对患者病情和预后的评估具有一定的参考作用。

Expression of High Mobility Group Protein -1, Ferritin and Endothelin in Patients with Hypertensive Intracerebral Hemorrhage and Its Clinical Significance

ABSTRACT Objective: To investigate the expression level of high mobility group protein -1 (HMGB-1), ferritin (SF) and vascular endothelin (ET-1) in patients with hypertensive intracerebral hemorrhage and its clinical significance. Methods: 96 patients with hypertensive cerebral hemorrhage who were treated in Liaocheng Second People''s Hospital Affiliated to Taishan Medical College from June 2014 to December 2017 were selected as the study group, and 80 healthy person in the hospital were used as the control group at the same time. According to the degree of nerve defect, the study group was divided into mild group with 28 cases, moderate group with 43 cases and severe group with 25 cases, the study group was divided into good prognosis group with 62 cases and poor prognosis group with 34 cases according to the prognosis. The levels of serum HMGB-1, SF and ET-1 in the study group and the control group, patients with different degrees of nerve defect and different prognosis were compared. The correlation between serum levels of HMGB-1, SF, ET-1 and national institute of acute stroke scale (NIHSS) in patients with hypertensive intracerebral hemorrhage were analyzed. Results: The serum levels of HMGB-1, SF and ET-1 in the study group were significantly higher than those in the control group (P<0.05). The level of serum HMGB-1, SF and ET-1 increased gradually with the increase of the degree of nerve defect, the differences were statistically significant (P<0.05). The serum HMGB-1, SF and ET-1 levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). Pearson correlation analysis showed that serum HMGB-1, SF, ET-1 levels were positively correlated with NIHSS scores in patients with hypertensive intracerebral hemorrhage (P<0.05). Conclusion: The expression level of serum HMGB-1, SF and ET-1 in patients with hypertensive intracerebral hemorrhage is closely related to the degree of nerve defect and prognosis. The higher the levels of HMGB-1, SF and ET-1, the worse the prognosis of patients. Detection of these indicators has a certain reference value for the evaluation of patients''condition and prognosis.