氧化樟脑注射液联合厄贝沙坦治疗心力衰竭的疗效及对血清NT-pro-BNP、NE水平的影响

目的:探讨氧化樟脑注射液联合厄贝沙坦治疗心力衰竭的疗效及对血清氨基末端脑钠肽前体(NT-pro-BNP)、去甲肾上腺素(NE)水平的影响。方法:选择2015年3月-2017年3月我院收治的心力衰竭患者80例进行研究,根据随机数表法将其分为观察组(n=41)和对照组(n=39)。对照组给予厄贝沙坦治疗,观察组在对照组的基础上加用氧化樟脑注射液治疗。比较两组患者的临床疗效、治疗前后血清NT-pro-BNP、NE水平、左室舒张末期内径(LVEDD)、左心室收缩末期容积(LVESV)、左心室收缩末内径(LVESD)、左心室射血分数(LVEE)水平的变化及不良反应的发生情况。结果:治疗后,观察组总有效率为95.12%,显著高于对照组(71.79%,P0.05)。两组患者治疗后血清NT-pro-BNP、NE、LVEDD、LVESD、LVESV水平均较治疗前显著降低,LVEE显著上升,且观察组血清NT-pro-BNP、NE、LVEDD、LVESD、LVESV水平明显低于对照组(P0.05),而LVEE显著高于对照组(P0.05)。观察组不良反应的发生率为4.88%,明显低于对照组(23.08%,P0.05)。结论:氧化樟脑注射液联合厄贝沙坦治疗心力衰竭的临床效果显著优于单用厄贝沙坦治疗,其可有效改善患者NT-pro-BNP、NE水平,且安全性较高。

Curative Efficacy of Camphor Oxide Injection Combined with Irbesartan in the Treatment of Heart Failure and Its Effects on the Serum Nt-pro-bnp and NE Levels

ABSTRACT Objective: To study the curative efficacy of Camphor oxide injection combined with irbesartan in the treatment ofHeart failure and its effects on the serum Amino terminal brain natriuretic peptide precursor (NT-pro-BNP), norepinephrine (NE). Methods: 80 patients with heart failure admitted to our hospital from March 2015 to March 2017 were selected and divided into the observation group (n=41) and the control group (n=39) according to the random number table method. The control group was treated with irbesartan, and the observation group was treated with camphor oxide injection on the basis of control group. The clinical efficacy, serum nt-pro-bnp, NE level, LVEDD, LVESV, LVESD, LVEE and incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate of observation group was 95.12%, which was significantly higher than that of the control group (71.79%, P<0.05). After treatment, the serum levels of nt-pro-bnp, NE, LVEDD, LVESD and LVESV in the two groups were significantly lower than those before treatment, while the LVEE was significantly higher. Moreover, the serum levels of nt-pro-bnp, NE, LVEDD, LVESD and LVESV in the observation group were significantly lower than those in the control group (P<0.05), while LVEE was significantly higher than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 4.88%, which was significantly lower than that in the control group(23.08%, P<0.05). Conclusion: The clinical effect of oxidized camphor injection combined with irbesartan was significantly better than that of irbesartan alone in the treatment of heart failure, which could effectively improve the levels of nt-pro-bnp and NE in patients with high safety.