2型糖尿病骨密度与冠状动脉钙化积分相关性研究

目的:探讨2型糖尿病患者冠脉钙化积分与骨密度的关系。方法:入选在2015年6月至2017年6月我科住院的2型糖尿病患者98例,按照性别以及糖化血红蛋白8%、低密度脂蛋白2.6 mmol/L、身高体重指数24 kg/m2为切点分为两组,进行冠脉动脉CT检查,计算冠脉动脉总钙化积分,依照钙化积分等于0为阴性组,大于0为阳性组。同时检测患者的骨密度、骨代谢指标、血钙、血磷等水平。比较冠脉钙化积分和骨代谢指标及骨密度的相关性。结果:1)男性患者中:阳性组糖化血红蛋白和颈部血管斑块形成明显高于阴性组,差异有统计学意义。女性患者中:阳性组年龄、颈部血管内膜厚度、高血压病史明显高于阴性组,差异有统计学意义。2)阳性、阴性两组之间骨代谢指标差异无统计学意义。3)男性患者中:阳性组腰椎骨密度明显高于阴性组,差异有统计学意义。女性患者中阳性组的腰椎骨密度明显低于阴性组,差异有统计学意义,在控制混杂因素以后,两组间差异无统计学意义。4)分别在男性和女性患者中按照年龄为60岁分为两组,两组间阳性组与阴性组的骨代谢指标及骨密度差异无统计学意义。结论:在2型糖尿病患者中,冠脉钙化积分和骨代谢以及骨密度之间无明显相关性。

The Relationship between Bone Mineral Density and Coronary Artery Calcification Score in Type 2 Diabetic Patients

ABSTRACT Objective: To investigate the relationship between coronary artery calcification score and bone mineral density in type 2 diabetic patients. Methods: 98 type 2 diabetes patients hospitalized in our department from June 2015 to June 2017 were measured BMD, coronary artery calcification score, bone metabolic markers, calcium and phosphorus. And patients were divided into two groups according to sex, HbA1c, LDL and BMI. The correlation between coronary calcification score and bone metabolic markers bone mineral density was compared. Results: 1)Among the male patients, the HbA1c and Cervical vascular plaque of the positive group was significantly higher than the negative group. Among the female patients, the age, cervical vessel intimal thickness and history of hypertension of the positive group were significantly higher than the negative group.2) there was no significant difference in bone metabolic markers between the two groups. 3) Among male patients: lumbar spine BMD of the positive group was significantly higher than the negative group. Amongthe female patients, the lumbar spine BMD of the positive group was significantly lower than the negative group. After controlling the confounding factors, there was no statistical difference between the two groups. 4) Divided into two groups according to age, there was no significant difference in bone metabolic markers and BMD. Conclusion: There is no significant correlation between coronary artery calcification score and bone metabolic markers, BMD in type 2 diabetes patients.