生长抑素联合双歧杆菌四联活菌治疗急性胰腺炎的效果及对肠粘膜屏障功能的影响

目的:探究生长抑素联合双歧杆菌四联活菌治疗急性胰腺炎的效果及对肠粘膜屏障功能的影响。方法:选取2015年8月～2018年8月我院收治的急性胰腺炎患者98例,根据患者入院先后顺序分为两组。对照组患者给予生长抑素治疗,观察组在对照组的基础上联合双歧杆菌四联活菌片治疗。比较两组患者的临床治疗效果,临床症状和指标的恢复时间及胃肠动力的恢复情况,治疗前后D-乳酸、二胺氧化酶(DAO)和尿乳果糖和甘露醇的比值(L/M)水平的变化。结果:治疗后,观察组患者的总有效率显著高于对照组(P0.05),腹痛、腹胀、腹膜刺激征、血淀粉酶和尿淀粉酶恢复正常时间均显著短于对照组(P0.05)。治疗后,两组患者的血清D-乳酸、DAO和L/M水平均较治疗前显著下降,且观察组以上指标均显著低于对照组(P0.05)。此外,观察组患者的腹内压显著低于对照组,肠鸣音恢复时间显著短于对照组,胃肠减压引流量显著低于对照组(P0.05)。结论:与单用生长抑素相比,生长抑素联合双歧杆菌四联活菌可更迅速缓解急性胰腺炎患者的临床症状及指标,恢复胃肠动力,并显著改善患者的肠粘膜屏障功能,利于患者的康复。

Clinical Efficacy of Somatostatin Combined with Bifidobacteria Tetraploid Live Bacteria in the Treatment of Acute Pancreatitis and Its Effect on the Intestinal Mucosal Barrier Function

ABSTRACT Objective: To investigate the efficacy of somatostatin combined with bifidobacteria tetraploid live bacteria in the treatment of acute pancreatitis and its effect on the intestinal mucosal barrier function. Methods: 98 cases of patients with acute pancreatitis admitted to our hospital from August 2015 to August 2018 were selected and divided into two groups according to the order of admission. The control group was given somatostatin, and the observation group was treated with bifidobacteria tetraplactis tablets on the basis of control group. The clinical treatment effect, clinical symptoms and indicators recovery time, gastrointestinal motility recovery, changes of D-lactic acid, DAO and L/M levels before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group (P<0.05). Patients in the observation group had significantly shorter recovery time for abdominal pain, abdominal distension, peritoneal irritation, blood amylase and urine amylase than those in the control group (P<0.05). After treatment, the serum D-lactic acid, DAO and L/M levels in both groups were significantly lower than those before treatment, and the above indicators in the observation group were significantly lower than those in the control group (P<0.05). In addition, the intra-abdominal pressure of patients in the observation group was significantly lower than control group, the recovery time of intestinal rumble was significantly shorter than control group, and the drainage volume of gastrointestinal decompression was significantly lower than control group (P<0.05). Conclusion: Compared with somatostatin alone, Somatostatin combined with bifidobacterium tetrabalone can more quickly relieve the clinical symptoms and indicators of patients with acute pancreatitis, restore the gastrointestinal motility and significantly improve the intestinal mucosal barrier function, which is conducive to the recovery of patients.