血清尿酸水平与冠心病的相关性研究

目的:众多关于血清尿酸水平与冠心病发展预后的相关性研究结果不一。本研究旨在通过对上海市第一人民医院入院患者的临床资料分析,研究血清尿酸水平与冠心病之间关系。方法:选择2008年7月至2009年4月上海地区、汉族就诊于我院的患者(123例),按入选排除标准,将入院患者分为冠心病组和对照组,分析尿酸水平与冠心病的关系。结果:男性(81.4%vs 51.6%)、吸烟(49.2%vs 21.9%)、血清尿酸水平升高(6.10±1.2 mg/dl vs 5.37±1.5 mg/dl)为冠心病的危险因素,统计值分别为0.02,0.02,0.005。血尿酸水平升高与血管病变严重程度成正相关,除单支血管病变外,双支血管病变患者尿酸水平为(6.11±1.07)mg/dl,对照组为(5.37±1.55)mg/dl,P0.05,三支病变患者尿酸水平为(6.84±1.29)mg/dl,P0.05。结论:血清尿酸水平升高与冠心病的发生、及病变严重程度密切相关。对冠心病患者的预防和治疗中,应重视对尿酸水平的监测。尿酸水平能否作为冠心病患者预后、转归的预测因子以及降低尿酸水平的治疗能否给冠心病患者带来收益有待进一步的研究。

Correlation of serumuric acid level with coronary artery disease

Objective： There is discrepancy in the results on the relationship between the level of serum uric acid and coronary artery disease. The present study was to analyze the clinical data of inpatients with coronary artery disease and explore the relationship between the level of serum uric acid and coronary artery disease. Methods： The study enrolled 123 participants who were admitted to Shanghai First People＇s Hospital from July, 2008 to April, 2009. These patients were enrolled as coronary artery disease group and control group. Clinical data were analyzed. Results：Male （81.4% vs 51.6%）, smoking （49.2% vs 21.9 %）, elevated serum uric acid level （6.10±1.2 mg/dl vs 5.37±1.5 mg/dl） were associated with coronary artery （P = 0.02, 0.02, 0.005, respectively）. Elevated serum uric acid level was positively correlated to the severity of coronary artery disease. Serum uric acid level in patients with two-vessel disease （6.11± 1.07 mg/dl ） and that in patients with three-vessel disease were significantly higher than that in control group（6.84± 1.29 mg/dl, P〈0.05）. Conclusions： Elevated serum uric acid level is associated with the prevalence as well as severity of coronary artery disease. Emphasis should also be placed on the evolving prevalence of hyperuricemia. More studies are therefore warranted to determine the association between hyperuricemia and cardiovascular outcomes, and the potential value of specific urate-lowering treatment on cardiovascular disease.