进展期胃癌根治术后早期复发的影响因素分析

目的:分析影响进展期胃癌根治术后早期复发的相关因素,为临床干预工作提供依据。方法:选取2009年6月至2012年7月本院收治的195例进展期胃癌患者作为研究对象,所有患者均接受胃癌根治术治疗,根据患者术后1年内复发与否将上述患者分为早期复发组(n=103)与对照组(n=92)。先后采用x2检验、非条件Logistic回归分析确定影响进展期胃癌根治术后早期复发的独立相关因素。结果:单因素分析发现,两组患者的肿瘤直径、Borrmann分型、Lauren分型、T分期、N分期、TNM分期、新辅助化疗、术后化疗等指标相比差异有统计学意义(P0.05),两组患者的性别、年龄、体质指数、肿瘤位置、分化程度、手术方式、腹腔镜手术等指标相比差异无统计学意义(P0.05)。非条件Logistic回归发现,N分期、TNM分期是影响进展期胃癌根治术后早期复发的独立危险因素,而新辅助化疗是独立保护因素。结论:进展期胃癌的N分期、TNM分期是其术后早期复发的独立危险因素,采取而新辅助化疗可降低进展期胃癌根治术后早期复发率。

Analysis of the Influencing Factors of Early Recurrence after Radical Resection for Patients with Advanced Gastric Cancer

Objective： To analyze the influencing factors of early recurrence after radical resection for advanced gastric cancer so as to provide theoretical evidence for clinical intervention. Methods： Totally 195 patients with advanced gastric cancer admitted into our hospital from June 2009 to July 2012 were selected as the objects of study. All patients underwent radical resection of gastric cancer. According to with or without recurrence one year after radical resection, these before-mentioned patients were divided into early recurrence group （n=103） and control group （n=92）. Chi-square test and unconditioned logistic regression analysis were applied to determine the independent relevant factors for early recurrence after radical resection. Results： The univariate analysis found that there were significant differences in tumor diameter, Borrmann type, Lauren type, T stage, N stage, TNM stage, neoadjuvant chemotherapy and postoperative chemotherapy between early recurrence group and control group （P〈0.05）, while there was no significant difference in gender, age ,body mass index, tumor location, degree of differentiation, surgical approaches and laparoscopic surgery between two groups （P〉0.05）. The unconditioned logistic regression analysis found that N stage and TNM stage were independent risk factors for early recurrence after radical resection, but neoadjuvant chemotherapy was an independent protective factor. Conclusion： N stage and TNM stage were independent risk factors of early recurrence after radical resection for advanced gastric cancer. Neoadjuvant chemotherapy can reduce the early recurrence rate after radical resection for advanced gastric cancer.