匹伐他汀临床应用的最新进展

匹伐他汀(pitavastatin)是新一代人工合成的降血脂类药物。该药是新一代HMG-COA还原酶抑制剂,用于治疗原发型高脂血症和混合型血脂障碍,能够显著降低LDL、TC、TG、及升高HDL-C。药物动力学性质优良,具有肝细胞选择性,并且毒性低,安全性好,具有抗动脉粥样硬化、促进血管生成和抗炎作用。本文就匹伐他汀的临床研究进展进行综述。

Pitavastatin the Ting Clinical Applications Progress

Pitavastatin is the new generation of synthetic lipid-lowering drugs. The drug is a new generation of HMG-COA reductase inhibitor, for the treatment of the original hairstyle hyperlipidemia and mixed dyslipidemia, low-density lipoprote in cholesterol (LDL-C), Total cholesterol(TC), triglycerides (TG), and also increase high-density lipoproteincho lesterol (HDL-C). The drug iswell tolerated and safe. Itnotonly haspotent cholesterol-lowering effects, but also has anti-atherosclerotic, angioge-Nesis-promoting and anti-inflammatory effects by selectively acting on liverv cells. The advancement of pitavastatin in current clinic newest researches are reviewed in this article.