5-HT_(1A)受体参与学习记忆的分子机制研究进展

5-HT(五羟色胺)能神经元是起源最早的神经元之一,在传统的神经元形成前,成长中的轴突就可释放5-HT,并且通过5-HT的各种亚型受体来实现不同的功能。近年来,随着5-HT、5-HTRs(五羟色胺受体)的基因克隆及5-HT受体选择性激动剂和拮抗剂的研究发展,5-HT系统在学习记忆中的作用越发明确,许多研究结果表明:5-HT系统在记忆的巩固、短时程记忆(STM)及长时程记忆(LTM)中起重要作用,5-HT1A受体更是在非脊椎动物及哺乳动物的脑中都高度表达,并通过相似的信号转导途径参与学习与记忆的形成和巩固。本文将介绍5-HT1A受体、5-HT1A受体激动剂、5-HT1A受体拮抗剂及其与学习记忆的联系,重点综述5-HT1A受体参与学习记忆的信号转导途径研究进展,讨论5-HT1A受体参与学习记忆的可能性分子神经生物学机制。

Research Progress of Molecular Aspects of 5-HT1A Receptor in Learning and Memory

Serotonergic neurons are among the earliest neurons to be generated, and 5-HT is released by growing axons before conventional synapses are established. Serotonin signaling is mediated by 14 receptor subtypes to realize different functional. In recent years, after the cloning and characterization of 5-HT, 5-HTRs, and the resultant development of selective agonist and antagonist compounds, our understanding of the role of serotonin systems in learning and memory has improved. Many researches suggests that serotonin systems play a role in memory consolidation, short- (STM) and long-term memory (LTM).That 5-HT1A receptor is densely expressed in brain regions is associated with learning and memory, both in invertebrate and mammalian species, by the similar signal transduction pathway. This review will introduce the relation between 5-HT1A receptor, 5-HT1A receptor agonists, 5-HT1A receptor antagonists and learning and memory. Especially review the research progress of 5-HT1A receptor signal transduction pathway in learning and memory, and discuss the potential molecular neurobiology mechanism.