alpha-硫辛酸对2 型糖尿病早期肾病的保护作用研究

目的：探讨注射用alpha-硫辛酸对2 型糖尿病早期肾病（DN）的保护作用。方法：将56 例2 型糖尿病早期肾病患者随机分为治 疗组28 例，采用注射alpha-硫辛酸加常规治疗；对照组28 例，仅给予常规治疗。治疗前后测定尿微量白蛋白排泄率（UAER）、超氧化 物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）水平。结果：与治疗前比较，治疗组UAER及MDA均显著降低（P＜0.05），SCr、 SOD及NO 显著升高（P＜0.05）。对照组SCr、UAER、SOD、MDA 及NO与治疗前比较差异无统计学意义（P＞0.05）。结论：注射用 alpha-硫辛酸能减少2型糖尿病肾病患者尿微量白蛋白的排泄，对早期肾病具有保护作用。

The Study of the Protective Effects of the Injection of alpha-Lipoic Acid on Type 2 Early Diabetes Nephropathy

Objective:To study the protective effects of the injection of alpha-lipoic acid on type 2 early diabetes nephropathy (DN).Methods:56 cases of early nephropathy in type 2 diabetes patients are randomly divided into treatment group 28 cases, use alpha-lipoic acid injection and conventional therapy; control group of 28 patients receive only conventional treatment. The urinary albumin excretion rate (UAER), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) levels are measured before and after treatment.Results:Compared with prior treatment, the UAER and MDA of treated group are significantly reduced (P<0.05), SCr, SOD and NO were significantly increased (P<0.05). The comparative difference between SCr, UAER, SOD, MDA and NO of Control group and before treatment has no statistical significance (P>0.05).Conclusion:Injection alpha-lipoic acid can reduce type 2 diabetic patients with nephropathy urinary albumin excretion, has a protective effect on early kidney disease.