| 维生素E自微乳化给药系统的制备 |
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| 引用本文： | 史玉红.维生素E自微乳化给药系统的制备[J].现代生物医学进展,2008,8(1):106-108. |
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| 作者姓名： | 史玉红 |
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| 作者单位： | 辽宁中医药大学附属医院中西医结合分院,辽宁,沈阳,110101 |
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| 摘 要： | 目的:研究维生素E自微乳的制备工艺.方法:考察了维生素E在不同油、乳化剂、助乳化剂中的溶解情况,筛选油相、乳化剂和助乳化剂.以假三角相图中形成微乳的面积为指标,采用正交设计表对处方进行优化,确定维生素E自乳化给药系统的最佳处方.结果:微乳最佳处方:油酸乙酯:Tween-80:丙二醇的比例为3:4:3.结论:该处方自乳化区域大,自微乳化速率快,所形成的乳剂稳定.
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| 关 键 词： | 维生素E 自微乳化 处方筛选 假三角相图 维生素 自微乳化 给药系统 Drug Delivery System Vitamin E 稳定 乳剂 速率 区域 比例 丙二醇 油酸乙酯 结果 最佳 自乳化 优化 处方 正交设计表 指标 面积 |
| 文章编号： | 1673-6273（2008）01-0106-03 |
| 收稿时间： | 2007-06-12 |
| 修稿时间： | 2007-07-30 |
Preparation of Vitamin E Self-microemulsifying Drug Delivery System |
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| SHI Yu-hong.Preparation of Vitamin E Self-microemulsifying Drug Delivery System[J].Progress in Modern Biomedicine,2008,8(1):106-108. |
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| Authors: | SHI Yu-hong |
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| Abstract: | Objective:To develop self-microemulsifying drug delivery system(SMEDDS)of vitamin E.Methods:The equilibri- um solubility of vitamin E in different compositions of oils,emulsifier and assistant emulsifier was investigated.The self-microemulsion formula was optimized in way of constructing the pseudo-ternary phase diagrams of blank SMEDDS and the studying of the self-mi- croemulsifying efficiency and the stability of drug-loaded SMEDDS.Results:The optimal self-microemulsion formula was composed of olive-oil,Tween-80,and propanediol.The ratio of them was 3:4:3.Conclusion:The formulation is reasonable,and the self-mi-croemul- sifying drug delivery system has a good stability. |
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| Keywords: | Self-microemusifying drug delivery systems Vitamin E Seeking formulas Pseudo-ternary phase diagrams |
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