男性不育与Y染色体

目的:观察精子数目异常与小Y染色体及内分泌性腺激素水平。方法:对262名少精及无精症患者检测染色体,并对其中11例小Y染色体及随机抽取的15例Y染色体正常的患者运用磁性分离酶免疫测定法分别检测性腺激素。结果:小Y染色体检出率为4.19%(11/262),其内分泌性腺激素均呈高卵泡刺激素、高黄体生成素和低睾酮水平,与Y染色体正常的无精及少精症患者相比较,差异有显著性(P<0.05)。而小Y染色体不同精子数组各内分泌性腺激素比较,差异无显著性(P>0.05)。结论:精子数目异常可能与小Y染色体有关,小Y染色体基因改变可能是导致其内分泌性腺激素的变化因素。

Relationship between Small Y Chromosome and the Endocrine Sexual Gland Hormone of 262 Male Infertile Patients

Objective: To assess the relationship between small Y chromosome and the endocrine sexual gland hormone(ESGH) level of oligospermia and azoospermia patients.Methods: Karyotype in peripheral blood samples collected from 262 oligospermia and azoospermia patients were examined.The ESGH levels were compared between 11 patients with small Y chromosomes and 15 patients randomly selected from 251 patients with normal size of Y chromosomes using MALA.Results: Compared with the levels of 15 patients with normal size of Y chromosomes,the prevalence of small Y chromosome was 4.19% among 262 oligospermia and azoospermia patients,and statistically higher levels of FSH,LH and lower levels of T were found among 11 patients with small Y chromosomes(P<0.05).When 11 patients with small Y chromosomes were classified into three different groups according to the number of sperms,no difference of ESGH levels was found among these groups.Conclusion: This study showed that the number of sperms could be related to small Y chromosome,whose gene imbalance could be the changing factor of the endocrine sexual gland hormone,which needs to be further studied in the future.