胰岛素受体基因多态性与2 型糖尿病的相关性

目的：探讨胰岛素受体基因（INSR）的第8外显子NaiⅠ多态性与湖北汉族人群2型糖尿痛的相关性；方法：采用同胞对（家系内对照）和随机病例-对照两种实验设计，并结合聚合酶链反应-限制性片断长度多态性（PCR—RFLP）技术分析了224个样本的INSR基因第8外显子NsiⅠ多态性，并洲定了身高、体重、腰围、臀围、血压和空腹血糖等生理指标；结果：两种实验设计中对照组与病例组的基因型和基因频率均无显著差异；结论：INSR基因在湖北汉族人群2型糖屎病的发生发展中可能不起主要作用。

Study on correlation between INSR gene polymorphismand type 2 diabetes mellitus

Objective: To investigate the correlation between insulin receptor ( INSR) gene Nsi ? polymorphism of exon 8 and type 2diabetes mellitus in Hubei Han people. Methods: Both sib- pairs and random case- control designs were used. The genotypes in 224 sampleswere examined using polymerase chain reaction- restriction fragment length polymorphism ( PCR- RFLP) . Height, weight, blood pressure andfasting blood glucose were measured. Results: In two experimental designs, there were no significant differences in the genotype and gene frequencybetween cases and controls. Conclusion: Type 2 diabetes mellitus may be little associated with INSR gene Nsi? polymorphism of exon8 in Hubei Han people.