金莲花液雾化吸入对慢性鼻窦炎功能性内窥镜术后患者鼻通气功能、生活质量和血清炎性因子的影响

目的:探讨金莲花液雾化吸入对慢性鼻窦炎(CRS)功能性内窥镜术后患者鼻通气功能、生活质量和血清炎性因子的影响。方法:选取2017年10月~2019年8月期间我院收治的CRS功能性内窥镜术后患者160例,采用随机数字表法将患者分为对照组(n=80)和研究组(n=80),对照组术后在常规治疗的基础上予以鼻腔生理盐水雾化吸入治疗,研究组在常规治疗的基础上予以金莲花液雾化吸入治疗,比较两组患者鼻通气功能鼻腔最小截面积(NMCSA)、鼻腔容积(NV)]、生活质量和血清炎性因子白介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)]及预后相关指标。结果:两组患者治疗10 d后NMCSA、NV均升高,且研究组高于对照组(P<0.05)。两组治疗10 d后情感职能、躯体疼痛、社会功能、生理功能、精神健康、活力、生理职能、总体健康的维度评分均升高,且研究组高于对照组(P<0.05)。两组治疗10 d后血清IL-5、TNF-α、PCT水平均较治疗前下降,且研究组低于对照组(P<0.05)。研究组术腔清洁时间、上皮化时间均短于对照组(P<0.05);研究组鼻黏液纤毛传输速度高于对照组(P<0.05)。结论:金莲花液雾化吸入治疗CRS功能性内窥镜术后患者,可有效改善其鼻通气功能及生活质量,抑制炎性反应,促进患者恢复。

Effect of Atomization Inhalation of Jinlianhua Liquid on Nasal Ventilation Function, Quality of Life and Serum Inflammatory Factors in Patients with Chronic Rhinosinusitis after Functional Endoscopic Surgery

Objective: To investigate the effect of atomization inhalation of Jinlianhua liquid on nasal ventilation function, quality of life and serum inflammatory factors in patients with chronic rhinosinusitis(CRS) after functional endoscopic surgery. Methods: From October 2017 to August 2019, 160 patients with CRS functional endoscopy who were admitted to our hospital were selected, they were randomly divided into control group(n=80) and study group(n=80) by random number table method. The control group was treated with nasal normal saline atomization inhalation on the basis of conventional treatment, and the study group was treated with Jinlianhua liquid atomization inhalation on the basis of conventional treatment. The nasal ventilation function minimum nasal area(NMCSA), nasal volume(NV)], quality of life, serum inflammatory factors interleukin-5(IL-5), tumor necrosis factor-α levels(TNF-α), procalcitonin(PCT)]and prognostic indicators were compared between the two groups. Results: The NMCSA and NV increased in the two groups at 10 days after treatment, and those in the study group were higher than those in the control group(P<0.05). The scores of emotional function, physical pain, social function, physiological function, mental health, vitality, physiological function and overall health of the patients in the two groups at 10 days after treatment were higher, and those in the study group were higher than those the control group(P<0.05). The serum levels of IL-5, TNF-α and PCT in the two groups at 10 days after treatment were lower than those before treatment, and those in the study group were lower than those the control group(P<0.05). The cleaning time of the operation cavity and epithelialization time in the study group were shorter than those in the control group(P<0.05). The nasal mucociliary transport speed in the study group was higher than that in the control group(P<0.05). Conclusion: The treatment of patients with CRS after functional endoscopy by atomization inhalation of Jinlianhua liquid, it can effectively improve the nasal ventilation function and quality of life, inhibit the inflammatory response,and it can promote the recovery of patients.