口腔正畸MIA技术对青少年安氏Ⅱ类错[牙合]畸形患者对龈沟液MMP-2表达水平的影响

目的:探讨口腔正畸微螺钉种植体支抗(Microscrew implant anchor,MIA)技术对青少年安氏Ⅱ类错牙合]畸形患者对龈沟液基质金属蛋白酶(Matrix metalloproteinase,MMP)-2表达水平的影响。方法:2016年1月1日至2019年12月31日选择在本院诊治的青少年安氏Ⅱ类错牙合]畸形患者86例,根据治疗方法把患者分为MIA组与对照组,各43例,对照组给予头帽口外弓支抗技术结合直丝弓矫治器治疗,MIA组给予MIA技术结合直丝弓矫治器治疗,检测龈沟液MMP-2表达水平变化情况。结果:MIA组正畸后6个月的总有效率为97.7%,显著高于对照组的81.4%(P<0.05)。两组正畸后6个月的SNA角、OB与OJ值低于正畸前,MIA组低于对照组(P<0.05),两组正畸前后SNB角在组内与组间对比差异都无统计学意义(P>0.05)。两组正畸后6个月的龈沟液MMP-2值低于正畸前,MIA组低于对照组(P<0.05)。结论:口腔正畸MIA技术在青少年安氏Ⅱ类错牙合]畸形患者的应用能抑制龈沟液MMP-2的表达,有利于改善患者的头颅与牙齿的X线指标,从而促进提高治疗效果。

Effect of Orthodontic MIA Technique on Expression of MMP-2 in Gingival Crevicular Fluid in Adolescents with Class Ⅱ Malocclusion

Objective: To explore the effect of orthodontic microscrew implant anchor(MIA) technique on the expression of matrix metalloproteinase(MMP)-2 in gingival crevicular fluid in adolescents with Class Ⅱ malocclusion. Methods: A total of 86 patients with adolescent Class II malocclusion, who were diagnosed and treated in Lianyungang Hospital from January 1, 2016 to December 31,2019, were selected and were randomly divided into MIA group(n=43) and contorl group(n=43). The control group was given head-gear external arch anchorage technique combined with straight wire appliance treatment, and the MIA group was given MIA technique combined with straight wire appliance treatment. The changes of gingival crevicular fluid MMP-2 expression level were detected.Results: Six months after orthodontics, the total effective rate(97.7 %) in the MIA group was significantly higher than that(81.4 %) in the control group(P<0.05);the SNA angle, OB and OJ values of the two groups were lower than before orthodontics, and the MIA group was lower than the control group(P<0.05). There was no statistically significant difference in the SNB angle values before and after orthodontics within and between two groups(P>0.05). The MMP-2 values of gingival crevicular fluid in the two groups 6 months after orthodontics were lower than before orthodontics, and the MIA group was lower than the control group(P<0.05). Conclusion: The application of orthodontic MIA technology in adolescents with Class Ⅱ malocclusion could inhibit the expression of MMP-2 in gingival crevicular fluid, which was beneficial to improving the X-ray indicators of the patient’s head and teeth, thereby increase treatment effectiveness.