肺功能康复训练联合肠外氨基酸营养支持对非小细胞肺癌化疗患者营养状态、癌因性疲乏及生活质量的影响

摘要 目的：探讨肺功能康复训练联合肠外氨基酸营养支持对非小细胞肺癌（NSCLC）化疗患者营养状态、癌因性疲乏及生活质量的影响。方法：选取2016年6月~2019年10月期间本院收治的NSCLC化疗患者137例。根据随机数字表法将患者分为对照组（68例，给予常规干预）、观察组（69例，在对照组基础上给予肠外氨基酸营养支持联合肺功能康复训练），对比两组干预前后的营养状态、肺功能、癌因性疲乏及生活质量。结果：与对照组相比，观察组干预后白蛋白、总蛋白、血红蛋白更高（P<0.05）。干预后观察组用力肺活量（FVC）、第1s用力呼气容积占预计值百分比（FEV₁%）、呼气峰流速值（PEF）高于对照组（P<0.05）。观察组干预后Piper 疲乏量表（PFS）的行为疲乏、情感疲乏、躯体疲乏、认知疲乏评分低于对照组（P<0.05）。观察组干预后生活质量评估量表（EORTC QLQ-C30）各维度评分较对照组更高（P<0.05）。结论：肺功能康复训练联合肠外氨基酸营养支持干预NSCLC化疗患者，可改善患者的营养状态及肺功能，缓解患者癌因性疲乏程度，改善其生活质量。

Effects of Lung Function Rehabilitation Training Combined with Parenteral Amino Acid Nutrition Support on Nutritional Status, Cancer-related Fatigue and Quality of Life in Patients with Non-small Cell Lung Cancer Undergoing Chemotherapy

ABSTRACT Objective: To investigate the effect of lung function rehabilitation training combined with parenteral amino acid nutrition support on nutritional status, cancer-related fatigue and quality of life of patients with non-small cell lung cancer (NSCLC) after chemotherapy. Methods: 137 chemotherapy patients with NSCLC who were admitted to our hospital from June 2016 to October 2019 were selected. According to random number table method, the patients were divided into control group (68 cases, given routine intervention ), observation group (69 cases, parenteral amino acid nutrition support+lung function rehabilitation training on the basis of the control group). The nutritional status, lung function, cancer-related fatigue and quality of life of the two groups before and after intervention were compared. Results: Compared with the control group, albumin, total protein and hemoglobin in the observation group after intervention were higher (P < 0.05). The forced vital capacity (FVC), forced expiratory volume as a percentage of predicted value in the first second (FEV₁%) and peak expiratory flow rate (PEF) in the observation group after intervention were higher than those in the control group (P < 0.05). after intervention, the scores of behavioral fatigue, emotional fatigue, physical fatigue and cognitive fatigue of Piper Fatigue Scale (PFS) in the observation group were lower than those in the control group (P < 0.05). The scores of each dimension of life assessment scale (EORTC QLQ-C30) of the observation group were higher than those of the control group after intervention (P < 0.05). Conclusion: Lung function rehabilitation training combined with parenteral amino acid nutrition support in the intervention of NSCLC chemotherapy patients can improve the nutritional status and lung function, relieve cancer-related fatigue and improve the quality of life.