谷红注射液和丁苯酞注射液联合Solitaire AB型支架取栓治疗急性缺血性脑卒中的临床研究

摘要 目的：探讨谷红注射液和丁苯酞注射液联合Solitaire AB型支架取栓治疗急性缺血性脑卒中（AIS）的临床疗效。方法：选择2018年1月到2020年12月期间攀枝花市中西医结合医院收治的AIS患者98例，依照随机数字表法分为观察组（50例）和对照组（48例）。对照组采用Solitaire AB型支架取栓治疗，观察组给予谷红注射液和丁苯酞注射液联合Solitaire AB型支架取栓治疗，两组均治疗14 d。治疗后进行临床疗效评价，比较两组治疗后的血管再通率和并发症发生率，比较两组治疗前后的美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数评分及全血高切黏度、全血低切黏度、血小板聚集率。结果：观察组的临床总有效率为84.00%（42/50），对照组为60.42%（29/48），两组比较差异有统计学意义（P<0.05）。观察组的血管再通率明显高于对照组（P<0.05）。两组治疗后血小板聚集率、全血低切黏度及全血高切黏度均明显低于治疗前（P<0.05），且观察组治疗后血小板聚集率、全血低切黏度及全血高切黏度均明显低于对照组（P<0.05）。治疗后观察组Barthel指数评分明显高于对照组（P<0.05），NIHSS评分明显低于对照组（P<0.05）。观察组的并发症发生率为6.00%（3/50），对照组为4.17%（2/48），两组比较差异无统计学意义（P>0.05）。结论：谷红注射液和丁苯酞注射液联合Solitaire AB型支架取栓治疗AIS的临床疗效显著，能够提高血管再通率，减轻神经功能缺损，改善患者的日常生活能力和血液流变学指标，且并发症较轻。

Clinical Study of Guhong Injection and Butylphthalide Injection Combined with Solitaire AB Stent Thrombectomy in the Treatment of Acute Ischemic Stroke

ABSTRACT Objective: To investigate the clinical effect of Guhong injection and butylphthalide injection combined with solitaire AB stent thrombectomy in the treatment of acute ischemic stroke (AIS). Methods: 98 AIS patients who were treated in Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to December 2020 were selected, they were randomly divided into observation group (50 cases) and control group (48 cases). The control group was treated with solitaire AB stent thrombectomy, the observation group was treated with Guhong injection and butylphthalide injection combined with solitaire AB stent thrombectomy, both groups were treated for 14 days. After the treatment, the clinical effect was evaluated, the vascular recanalization rate and the incidence of complications were compared, and the National Institutes of Health Stroke Scale (NIHSS) score, Barthel index, high shear viscosity, low shear viscosity and platelet aggregation rate of the two groups before and after the treatment were compared. Results: The total clinical effective rate was 84.00%(42/50) in the observation group and 60.42% (29/48) in the control group, there was difference between the two groups (P<0.05). The recanalization rate of the observation group was higher than that of the control group (P<0.05). After treatment, platelet aggregation rate, low shear viscosity and the whole blood high shear viscosity in the two groups were significantly lower than those before treatment(P<0.05), while platelet aggregation rate, low shear viscosity and the whole blood high shear viscosity in the observation group were lower than those in the control group (P<0.05). After treatment, Barthel index score of the observation group was higher than that of the control group (P<0.05), NIHSS score was lower than that of the control group (P<0.05). The incidence of complications was 6.00% (3/50) in the observation group and 4.17% (2/48) in the control group, there was no difference between the two groups(P>0.05). Conclusion: Butylphthalide injection combined with Guhong injection and solitaire AB stent thrombectomy has a significant clinical effect in the treatment of AIS, which can improve the recanalization of blood vessels, reduce the neurological deficit, improve the ability of daily life and hemorheology indexes of patients, and has less complications.