银杏叶提取物注射液联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及对血液流变学和炎症因子的影响

摘要 目的：观察急性脑梗死（ACI）在溶栓治疗的基础上联合银杏叶提取物注射液治疗后的疗效，并分析该治疗方案对炎症因子、血液流变学的影响。方法：选择2019年6月到2020年10月期间来我院接受诊治的ACI患者60例，按照入院奇偶顺序法将患者分为对照组（奇，30例，阿替普酶静脉溶栓治疗）和观察组（偶，30例，银杏叶提取物注射液联合阿替普酶静脉溶栓治疗），疗程为7 d。对比两组治疗7 d后的疗效，对比两组治疗前、治疗7 d后的血液流变学、美国国立卫生研究院卒中量表（NIHSS）评分、炎症因子、日常生活能力量表（ADL）评分，观察两组治疗期间不良反应发生情况。结果：观察组的临床总有效率较对照组高（P<0.05）。观察组治疗7 d后NIHSS评分低于对照组，ADL评分高于对照组（P<0.05）。观察组治疗7 d后超敏C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平低于对照组（P<0.05）。观察组治疗7 d后血小板压积、血小板分布宽度、纤维蛋白原低于对照组（P<0.05）。两组不良反应发生率对比，差异无统计学意义（P>0.05）。结论：银杏叶提取物注射液联合阿替普酶静脉溶栓治疗ACI患者疗效明确，可改善血液流变学，减少神经功能损伤，降低炎症因子水平，提高患者生活自理能力，且安全性好。

Effect of Ginkgo Biloba Extract Injection Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and Its Influence on Hemorheology and Inflammatory Factors

ABSTRACT Objective: To observe the curative effect of acute cerebral infarction (ACI) combined with Ginkgo biloba extract injection on the basis of thrombolytic therapy, and to analyze the effect of the treatment on inflammatory factors and hemorheology. Methods: 60 patients with ACI who were admitted to our hospital from June 2019 to October 2020 were selected, they were divided into control group (n=30, intravenous thrombolytic therapy with alteplase) and observation group (n=30, intravenous thrombolytic therapy with Ginkgo biloba extract injection combined with alteplase) according to the parity order of admission. The course of treatment was 7 d. The curative effects of the two groups were compared 7 d after treatment, hemorheology, national Institutes of health Stroke Scale (NIHSS), inflammatory factors and activities of daily living scale (ADL) scores before and 7d after treatment were compared between the two groups, the incidence of adverse reactions in the two groups were observed. Results: The total effective rate of the observation group was higher than that of the control group (P<0.05). 7 d after treatment, NIHSS score of observation group was lower than that of control group, ADL score of observation group was higher than that of control group (P<0.05). 7 d after treatment, the levels of high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) in the observation group were lower than those in the control group (P<0.05). 7 d after treatment, the hematocrit, platelet distribution width and fibrinogen in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Ginkgo biloba extract injection combined with alteplase intravenous thrombolytic therapy in patients with ACI has clear curative effect, can improve hemorheology, reduce nerve function damage, reduce the level of inflammatory factors, improve the self-care ability of patients with good safety.