参苓白术散联合推拿治疗急性轮状病毒感染性腹泻患儿的疗效及对胃肠激素和免疫力的影响

摘要 目的：探讨参苓白术散联合推拿治疗急性轮状病毒感染性腹泻患儿的疗效及对胃肠激素和免疫力的影响。方法：选取2018年12月~2019年12月期间我院收治的80例急性轮状病毒感染性腹泻患儿，按照随机数字表法分为对照组（n=40）和研究组（n=40），对照组患儿予以常规基础治疗，研究组在对照组基础上给予参苓白术散联合推拿治疗，比较两组患儿疗效、中医证候积分、胃肠激素指标胃泌素（GAS）、胃动素（MOT）以及血管活性肠肽（VIP）]和免疫力指标免疫球蛋白 A（IgA）、免疫球蛋白 G（IgG）、CD4⁺ /CD8⁺]，记录两组不良反应发生情况。结果：研究组治疗7 d后的临床总有效率为95.00%（38/40），高于对照组的67.50%（27/40）（P<0.05）。两组治疗7 d后GAS、MOT、VIP均下降，且研究组低于对照组（P<0.05）。两组治疗7 d后IgA、IgG、CD4⁺ /CD8⁺均升高，且研究组高于对照组（P<0.05）。两组治疗期间不良反应发生率对比未见统计学差异（P>0.05）。两组治疗7 d后腹痛、大便次数、大便性状、体温中医证候积分均降低，且研究组低于对照组（P<0.05）。结论：参苓白术散联合推拿治疗急性轮状病毒感染性腹泻患儿，疗效显著，可有效改善患儿胃肠状况，提高患儿免疫力，且安全性较好。

Effects of Shenling Baizhu Powder Combined with Massage on Gastrointestinal Hormones and Immunity in Children with Acute Rotavirus Infection Diarrhea

ABSTRACT Objective: To investigate the effect of Shenling Baizhu powder combined with massage on gastrointestinal hormones and immunity in children with acute rotavirus diarrhea. Methods: 80 children with acute rotavirus infection diarrhea who were admitted to our hospital from December 2018 to December 2019 were selected, they were divided into control group (n=40) and study group (n=40) by random number table. Children in the control group were treated with routine basic treatment. The study group was treated with Shenling Baizhu powder combined with massage on the basis of the control group. The curative effect, TCM syndrome integral, and gastrointestinal hormone indexes gastrin (GAS), moxa (MOT) and vasoactive intestinal peptide (VIP)] and immune indexes immunoglobulin A (IgA), immunoglobulin G (IgG), CD4⁺ /CD8⁺] of the two groups were compared. Adverse reactions were recorded in both groups. Results: The total clinical effective rate of the study group at 7 d after treatment was 95.00% (38/40), which was higher than 67.50% (27/40) of the control group (P<0.05). The GAS, MOT and VIP of the two groups at 7d after treatment were all decreased, and those of the study group were lower than those of the control group (P<0.05). The levels of IgA, IgG and CD4⁺ /CD8⁺ of the two groups at 7 d after treatment were all increased, and those of the study group were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The scores of abdominal pain, stools frequency, stools characteristics and body temperature of TCM syndromes were all decreased of the two groups at 7d after treatment, and the study group was lower than the control group (P<0.05). Conclusion: Shenling Baizhu powder combined with massage is effective in the treatment of children with acute rotavirus infection diarrhea. It can effectively improve the gastrointestinal status, improve the immunity of children, and has good safety.