血清Gal-3、NT-pro-BNP及hs-CRP水平与慢性心力衰竭超声心动图指标的相关性研究

摘要 目的：探讨血清半乳糖凝聚素-3（Gal-3）、氨基末端脑钠肽前体（NT-pro-BNP）、超敏C反应蛋白（hs-CRP）水平与慢性心力衰竭超声心动图指标的相关性。方法：选择2018年2月～2019年10月我院收治的慢性心功能衰竭患者112例作为研究组，按美国心脏病协会（NYHA）分级分为Ⅱ级组43例、Ⅲ级组39例、Ⅳ级组30例，另选择同期我院体检的健康人员60例作为对照组，比较研究组和对照组及不同心功能分级的慢性心力衰竭患者血清Gal-3、NT-pro-BNP、hs-CRP 水平和超声心动图指标，分析慢性心力衰竭患者上述指标之间的相关性。结果：研究组血清Gal-3、NT-pro-BNP、hs-CRP水平显著高于对照组，E峰与A峰比值（E/A）及左心室射血分数（LVEF）显著低于对照组（P＜0.05）。随NYHA分级增加，慢性心力衰竭患者血清Gal-3、NT-pro-BNP、hs-CRP水平逐渐升高，E/A和LVEF逐渐降低（P＜0.05）。经Pearson相关性分析显示，慢性心功能衰竭患者血清Gal-3、NT-pro-BNP、hs-CRP分别与E/A、LVEF水平呈负相关关系（P＜0.05）。结论：慢性心力衰竭患者血清Gal-3、NT-pro-BNP、hs-CRP水平异常升高，与超声心动图指标相关，检测Gal-3、NT-pro-BNP、hs-CRP有助于慢性心力衰竭的诊断和病情评估。

Correlation Study between the Levels of Serum Gal-3, NT-pro-BNP, hs-CRP and the Echocardiographic Indexes of Chronic Heart Failure

ABSTRACT Objective: To investigate the correlation between the levels of serum galactose-3 (Gal-3), N-terminalpro-brain natriuretic peptide (NT-pro-BNP), hypersensitive C-reactive protein (hs-CRP) and echocardiographic indexes of chronic heart failure. Methods: 112 patients with chronic heart failure who were admitted to our hospital from February 2018 to October 2019 were selected as study group, they were divided into Grade II 43 cases, grade III 39 cases and grade IV 30 cases of the American Heart Association (NYHA), and 60 healthy people in our hospital at the same time were selected as the control group. The levels of serum Gal-3, NT-pro-BNP, hs-CRP and echocardiographic indexes of chronic heart failure patients with different heart function grades were compared between the study group and the control group, and the correlation between the above indexes in chronic heart failure patients were analyzed. Results: The levels of serum Gal-3, NT-Pro-BNP and hs-CRP in the study group were significantly higher than those in the control group, and the ratio of peak E to peak A (E/A) and left ventricular ejection fraction (LVEF) were significantly lower than those in the control group (P<0.05). With the increase of NYHA grade, the levels of serum Gal-3, NT-Pro-BNP and hs-CRP in patients with chronic heart failure gradually increased, the E/A and LVEF decreased gradually (P<0.05). The Pearson correlation analysis showed that the serum levels of Gal-3, NT-pro-BNP and hs-CRP were negatively correlated with the E/A and LVEF levels respectively (P<0.05). Conclusion: The levels of serum Gal-3, NT-pro-BNP and hs-CRP in patients with chronic heart failure are abnormally high, which were related to echocardiographic indexes, the detection of Gal-3, NT-Pro-BNP and hs-CRP is helpful for the diagnosis and evaluation of chronic heart failure.