不同类型缺血性脑血管病血清VCAM-1、MMP-2、TIMP-1的表达及与神经功能缺损的关系分析

摘要 目的：探讨不同类型缺血性脑血管病血清血管细胞粘附分子-1（VCAM-1）、基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶抑制剂1（TIMP-1）的表达及与神经功能缺损的关系。方法：选择2016年1月至2020年1月我院接诊的98例缺血性脑血管病患者为本研究对象，其中脑梗死55例设为脑梗死组，短暂性脑缺血发作组43例，并选择我院同期体检中心健康者50作为对照组，分析三组血清VCAM-1、MMP-2、TIMP-1水平之间的差异及不同神经缺损程度血清VCAM-1、MMP-2、TIMP-1水平、美国国立卫生研究院卒中量表（NIHSS）评分变化情况，及其之间的相关性。结果：脑梗死组血清VCAM-1、MMP-2、TIMP-1水平及NIHSS评分显著高于短暂性脑缺血发作组和对照组，差异显著（P＜0.05）；短暂性脑缺血发作组血清VCAM-1、MMP-2、TIMP-1水平及NIHSS评分显著高于对照组，差异显著（P＜0.05）；重度神经缺损组血清VCAM-1、MMP-2、TIMP-1水平及NIHSS评分显著高于中度神经缺损组和轻度神经缺损组，差异显著（P＜0.05）；中度神经缺损组血清VCAM-1、MMP-2、TIMP-1水平及NIHSS评分显著高于轻度神经缺损组，差异显著（P＜0.05）；相关性分析结果中显示，血清VCAM-1、MMP-2、TIMP-1均和NIHSS评分呈正相关（r=0.603, 0.915, 0.778，P＜0.05）。结论：血清VCAM-1、MMP-2、TIMP-1在缺血性脑血管病患者中表达异常，神经缺损越严重血清VCAM-1、MMP-2、TIMP-1表达越高。

Analysis of the Expression of vCAM-1, MMP-2 and TIMP-1 in Serum of Different Types of Ischemic Cerebrovascular Diseases and Their Relationship with Nurological Impairment

ABSTRACT Objective: To study Analysis of theexpression of Vascular cell adhesion molecule-1(VCAM-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-1 (TIMP-1) in serum of different types of ischemic cerebrovascular diseases and their relationship with neurological impairment. Methods: 98 cases of patients with ischemic cerebrovascular disease in our hospital from January 2016 to January 2020 were selected as the research objects, including 55 cases of cerebral infarction as cerebral infarction group, 43 cases of transient ischemic attack group, and 50 healthy people in the physical examination center of our hospital at the same period as the control group. The differences of serum VCAM-1, MMP-2, TIMP-1 levels and serum VCAM-1, MMP-2, TIMP-1 levels in three groups were analyzed TIMP-1 level, NIHSS score changes, and their correlation. Results: The serum levels of VCAM-1, MMP-2, TIMP-1 and NIHSS scores in cerebral infarction group were significantly higher than those in TIA group and control group(P<0.05). The serum levels of VCAM-1, MMP-2, TIMP-1 and NIHSS score in TIA group were significantly higher than those in control group(P<0.05). Serum VCAM-1, MMP-2, TIMP-1 and NIHSS scores in severe nerve defect group were significantly higher than those in moderate nerve defect group and mild nerve defect group, the differences were significant(P<0.05). The serum levels of VCAM-1, MMP-2, TIMP-1 and NIHSS score in moderate nerve defect group were significantly higher than those in mild nerve defect group(P<0.05). Correlation analysis results showed that serum VCAM-1, MMP-2, TIMP-1 were positively correlated with NIHSS score (r=0.603,0.915,0.778, P<0.05). Conclusion: Serum VCAM-1, MMP-2 and TIMP-1 were abnormally expressed in patients with ischemic cerebrovascular disease, and the more serious the nerve defect was, the higher the expression of VCAM-1, MMP-2 and TIMP-1 was.