仙灵骨葆胶囊联合改良髓芯减压人工骨植入术对股骨头坏死患者血液流变学和生活质量的影响

摘要 目的：探讨仙灵骨葆胶囊联合改良髓芯减压人工骨植入术治疗股骨头坏死的疗效及对血液流变学和生活质量的影响。方法：选取2015年3月~2018年12月期间我院收治的股骨头坏死患者60例，上述患者根据随机数字表法分为对照组（n=30）和研究组（n=30），对照组患者予以改良髓芯减压人工骨植入术治疗，研究组在对照组基础上联合仙灵骨葆胶囊治疗，对两组患者疗效、血液流变学、生活质量、髋关节功能及并发症情况进行比较。结果：研究组治疗后12个月的临床总有效率93.33%（28/30）高于对照组70.00%（21/30）（P<0.05）。两组患者治疗后Harris髋关节功能评分均升高，且研究组高于对照组（P<0.05）。两组患者治疗后12个月生活质量测定量表(SF-36)各维度评分均升高，且研究组高于对照组（P<0.05）。两组患者治疗后12个月全血黏度、红细胞压积、纤维蛋白原均降低，且研究组低于对照组（P<0.05）。两组并发症发生率比较无明显差异(P>0.05)。结论：仙灵骨葆胶囊联合改良髓芯减压人工骨植入术治疗股骨头坏死，疗效显著，可有效改善患者髋关节功能、血液流变学及提高生活质量，且安全性较好。

Effect of Xianling Gubao Capsule Combined with Modified Core Decompression and Artificial Bone Implantation on Hemorheology and Quality of Life in Patients with Femoral Head Necrosis

ABSTRACT Objective: To investigate the curative effect of xianling gubao capsule combined with modified core decompression and artificial bone implantation in the treatment of patients with femoral head necrosis and its influence on hemorheology and quality of life. Methods: From March 2015 to December 2018, 60 patients with osteonecrosis of the femoral head in our hospital were selected. The above patients were divided into the control group (n=30) and the study group (n=30) according to the random number table method. The control group was treated with modified core decompression and artificial bone implantation. The study group was treated with xianling gubao capsule on the basis of the control group, and the effect, hemorheology and quality of life, hip function and complications of the two groups were compared. Results: The total clinical effective rate of the study group 12 months after treatment was 93.33% (28/30) higher than 70.00% (21/30) of the control group (P<0.05). After treatment, Harris hip joint function score of the two groups increased, and the study group was higher than the control group (P<0.05). 12 months after treatment, the scores of quality of life measurement scale (SF-36) in the two groups increased, and the study group was higher than the control group (P<0.05). 12 months after treatment, the whole blood viscosity, hematocrit and fibrinogen of the two groups decreased, and the study group was lower than the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: Xianling gubao capsule combined with modified core decompression and artificial bone implantation for the treatment of femoral head necrosis has a significant effect, which can effectively improve the hip joint function, hemorheology and enhance quality of life of patients, and has a good safety.